Sulphotransferases acting on mucin-type oligosaccharides

被引：80
作者：
Brockhausen, I [1 ]
机构：
[1] Queens Univ, Dept Med, Kingston, ON, Canada
[2] Queens Univ, Dept Biochem, Kingston, ON, Canada
[3] Queens Univ, Human Mobil Res Ctr, Kingston, ON, Canada
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2003年 / 31卷
关键词：
biosynthesis of glycoproteins; inflammation; O-glycan; mucin; sulphotransferase;
D O I：
10.1042/BST0310318
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review summarizes the occurrence, properties and role in mucin O-glycosylation pathways of the various members of glycoprotein sulphotransferase families. Although a number of sulphotransferases have been cloned that act on mucin-type substrates in vitro, it is still difficult to determine exactly which enzymes are responsible for mucin sulphation in vivo. Sulphotransferases play a critical role in determining the chemical, physical and biological properties of mucins. Several of these enzymes have been shown to differ in expression and activity in cancer and inflammation.
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收藏
页码：318 / 325
页数：8
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