Activating Na+-K+ ATPase: A potential cardioprotective therapy during early hemorrhagic shock

被引：3

作者：

Li, Weijing ^{[1
]}

Wang, Xuanlin ^{[1
]}

He, Min ^{[1
]}

Wang, Chunyan ^{[1
]}

Qiao, Zhixin ^{[1
]}

Wang, Qingjun ^{[2
]}

Ren, Suping ^{[1
]}

Yu, Qun ^{[1
]}

机构：

[1] Beijing Inst Transfus Med, Beijing 100850, Peoples R China

[2] Shenzhou Biol & Technol Co Ltd, Hohhot 010206, Inner Mongolia, Peoples R China

来源：

MEDICAL HYPOTHESES | 2014年 / 83卷 / 06期

关键词：

RAT; HEART; SURVIVAL;

D O I：

10.1016/j.mehy.2014.09.018

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cell volume and resting potential are heavily affected by the activity of Na+-K+ ATPase (NKA, Na+-K+ pump), an essential membrane protein that regulates plasma K+ and Na+ levels. It is generally accepted that the ineffective perfusion of body tissues inhibits NKA activity and that NKA activity and heart failure are closely related. Recently, research has proven that the activation of NKA provides significant cardioprotection against ischemic injury. Based on these data, we propose that NKA stimulation could attenuate the development of heart arrhythmia during the early phase of hemorrhagic shock. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：685 / 687

页数：3

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