One of the main challenges of modern engineering seismology is the mitigation of the adverse consequences of earthquakes. Although modern engineering techniques allow for the designing of earthquake-resistant structures, the ability to predict more reliable ground-motion estimates and associated uncertainties is needed. With this aim, this study investigated the possibility of using data recorded during an earthquake to improve the empirical ground-motion prediction equations (GMPEs). In particular, we propose a procedure that updates the coefficients of an initial GMPE to account for the specific features of a seismic source and propagation medium. We applied the technique in the immediate postevent time period of three well-recorded earthquakes that occurred recently in Italy and caused casualties and significant damage: the 6 April 2009 M-w 6.3 L'Aquila earthquake, the 20 May 2012 M-w 5.9 Emilia earthquake, and the 25 October 2012 M-w 5.2 Pollino earthquake. For possible future development, using the same earthquakes and the networks with which they were recorded, we also explored the potential of the technique as a possible real-time application, as in the case of earthquake early warning systems.