Low expression of miR-195 is associated with cell proliferation, glycolysis and poor survival in estrogen receptor (ER)-positive but not in triple negative breast cancer

被引：0

作者：

Tokumaru, Yoshihisa ^{[1
,2
]}

Oshi, Masanori ^{[1
,3
]}

Patel, Ankit ^{[1
]}

Katsuta, Eriko ^{[1
]}

Yan, Li ^{[4
]}

Angarita, Fernando A. ^{[1
]}

Dasgupta, Subhamoy ^{[5
]}

Nagahashi, Masayuki ^{[6
]}

Matsuhashi, Nobuhisa ^{[2
]}

Futamura, Manabu ^{[2
]}

Yoshida, Kazuhiro ^{[2
]}

Takabe, Kazuaki ^{[1
,3
,6
,7
,8
,9
]}

机构：

[1] Roswell Park Canc Inst, Dept Surg Oncol, Breast Surg, Elm & Carlton St, Buffalo, NY 14263 USA

[2] Gifu Univ, Grad Sch Med, Dept Surg Oncol, I-1 Yanagido, Gifu 5011194, Japan

[3] Yokohama City Univ, Grad Sch Med, Dept Surg Gastroenterol, Yokohama, Kanagawa 2360004, Japan

[4] Roswell Park Comprehen Canc Ctr, Dept Biostat & Bioinformat, Buffalo, NY 14263 USA

[5] Roswell Park Comprehens Canc Ctr, Dept Stress Biol, Buffalo, NY 14203 USA

[6] Niigata Univ, Grad Sch Med & Dent Sci, Dept Surg, Niigata 9518510, Japan

[7] SUNY Buffalo, SUNY Coll Buffalo, Jacobs Sch Med & Biomed Sci, Dept Surg, Buffalo, NY 14263 USA

[8] Tokyo Med Univ, Dept Breast Oncol & Surg, 6-7-1 Nishishinjuku, Tokyo, Shinjuku 1608402, Japan

[9] Fukushima Med Univ, Sch Med, Dept Breast Surg, Fukushima 9601295, Japan

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2021年 / 11卷 / 06期

关键词：

MicroRNA; miR-195; cell proliferation; glycolysis; breast cancer; TCGA; METABRIC; GSEA; NEOADJUVANT CHEMOTHERAPY; METABOLISM; FEATURES; METASTASIS; INHIBITION; GLUCOSE; TARGET; GROWTH;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MiR-195 is a tumor suppressive microRNA in breast cancer. Its clinical relevance remains debatable as it has only been studied via in vitro experiments or small cohort studies. We analyzed a total of 2,038 patients in the TCGA and METABRIC cohorts to assess whether low miR-195 expressing tumors are associated with aggressive cancer characteristics and poor prognostic outcomes. The median cutoff of miR-195 expression was used to split the groups into miR-195 high and low groups. Low miR-19 expressing tumors demonstrated high cell proliferating features by enriching the gene sets associated with cell proliferation, MKI67 expression and pathological grade. One-third of the top target miR-195 genes were related to cell proliferation. Low miR-195 expressing tumors were associated with both pro-cancerous and anti-cancerous immune cells. Low miR-195 expressing tumors were associated with enhanced glycolysis and poor survival in ER-positive tumors, but not other subtypes of breast cancer. In conclusion, low expression of miR-195 in ER-positive breast cancer was associated with enhanced cancer cell proliferation, glycolysis, and worse overall survival.

引用

页码：3320 / +

页数：16

共 59 条

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