Hypomyelination Associated With Bovine Viral Diarrhea Virus Type 2 Infection in a Longhorn Calf

被引：12

作者：

Porter, B. F. ^{[1
]}

Ridpath, J. F. ^{[2
]}

Calise, D. V. ^{[1
]}

Payne, H. R. ^{[1
]}

Janke, J. J. ^{[3
]}

Baxter, D. G. ^{[1
]}

Edwards, J. F. ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Vet Pathobiol, Coll Vet Med & Biomed Sci, College Stn, TX 77843 USA

[2] Natl Anim Dis Ctr, Ames, IA USA

[3] Texas A&M Univ, Dept Large Anim Clin Sci, Coll Vet Med & Biomed Sci, College Stn, TX 77843 USA

来源：

VETERINARY PATHOLOGY | 2010年 / 47卷 / 04期

关键词：

Bovine viral diarrhea virus; cattle; electron microscopy; hypomyelination; immunohistochemistry; BORDER DISEASE; CONGENITAL TREMOR; SPINAL-CORD; FETAL; LESIONS; CALVES; BVDV;

D O I：

10.1177/0300985810370014

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A newborn Longhorn heifer calf presented with generalized tremors, muscle fasciculations, ataxia, and nystagmus. At necropsy, no gross central nervous system lesions were observed. Histologically, the brain and spinal cord had mild to moderate diffuse microgliosis and astrocytosis, minimal nonsuppurative encephalitis, and decreased myelin staining. Ultrastructural examination revealed thinning and absence of myelin sheaths. Various cell types were immunohistochemically positive for bovine viral diarrhea virus (BVDV). Noncytopathogenic BVDV was isolated from the brain and identified as BVDV type 2 by phylogenetic analysis. BVDV-induced hypomyelination is rare and analogous to lesions in neonates infected with border disease and classical swine fever viruses. This is the first documented case of hypomyelination in a calf specifically attributed to BVDV type 2 and the first description of the ultrastructural appearance of BVDV-induced hypomyelination.

引用

页码：658 / 663

页数：6

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