Neuropsychologic deficits in schizophrenia - Relation to social function and effect of antipsychotic drug treatment

被引:104
作者
Meltzer, HY [1 ]
Thompson, PA [1 ]
Lee, MA [1 ]
Ranjan, R [1 ]
机构
[1] CASE WESTERN RESERVE UNIV,SCH MED,DEPT PSYCHIAT,LAB BIOL PSYCHIAT,CLEVELAND,OH 44106
关键词
schizophrenia; cognitive function; neuroleptic; quality of life;
D O I
10.1016/0893-133X(95)00202-O
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cognitive impairment is present in the majority of schizophrenic patients, even at the onset of psychosis. It is a relatively stable characteristic in most patients, usually with little progression over the course of illness, but sometimes progresses to severe dementia. The results of studies of the effects of typical neuroleptic drugs on cognitive functioning in schizophrenia are conflicting. Clozapine, which has superior antipsychotic effects compared to typical neuroleptic drugs, has been reported to improve executive function, verbal fluency, attention, and recall memory in two of three studies. Cognitive measures predict work function and overall outcome on clozapine as assessed by the Global Assessment Scale and Quality-of-Life Scale in neuroleptic-resistant schizophrenia. Improvement in cognitive function by clozapine may be a major reason for expanding its currently limited utilization.
引用
收藏
页码:S27 / S33
页数:7
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