New opportunities for drug delivery carrier of natural allophane nanoparticles on human lung cancer A549 cells

被引：8
作者：
Toyota, Yusuke [1 ]
Okamoto, Masami [1 ]
Arakawa, Shuichi [1 ]
机构：
[1] Toyota Technol Inst, Grad Sch Engn, Adv Polymer Nanostruct Mat Engn, Tempaku Ku, 2-12-1 Hisakata, Nagoya, Aichi 4688511, Japan
来源：
APPLIED CLAY SCIENCE | 2017年 / 143卷
关键词：
Allophane nanoparticles; Cisplatin; Complexation; A549; cells; Apoptosis; CLAY; HALLOYSITE; RESISTANCE; MECHANISMS; RELEASE; SYSTEMS;
D O I：
10.1016/j.clay.2017.04.017
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The complexation of allophane nanoparticles with cisplatin, cis-dichlorodianunineplatinum (II) (CDDP) to deliver platinum prodrug into cancer cells was investigated. Using human lung carcinoma (A549) cells, profound studies including cellular uptake (endocytosis) analysis of allophane nanoparticle, cell cycle arrest abilities and apoptosis induction profiles were discussed in detail. As well as the features against A549 cells to emerge a promising strategy to enhance their anti-cancer activity and to mitigate side-effects were discussed.
引用
收藏
页码：422 / 429
页数：8
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