Calcium and vitamin D: What is known about the effects on growing bone

被引：27

作者：

Demay, Marie B.

Sabbagh, Yves

Carpenter, Thomas O.

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Endocrine Unit, Boston, MA 02115 USA

[2] Yale Univ, Dept Pediat, New Haven, CT 06520 USA

来源：

PEDIATRICS | 2007年 / 119卷

关键词：

vitamin D receptor; ablation; hypophosphatemia; rickets; MINERAL ION HOMEOSTASIS; RECEPTOR-ABLATED MICE; PHOSPHATE IONS; HYPERTROPHIC CHONDROCYTES; APOPTOSIS; RICKETS; HYPERPARATHYROIDISM; ALOPECIA;

D O I：

10.1542/peds.2006-2023F

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The objective of these investigations was to determine if the receptor- dependent effects of 1,25-dihydroxyvitamin D were essential for normal skeletal growth. Mice with targeted ablation of the vitamin D receptor were engineered, and the skeletal consequences of vitamin D receptor ablation were studied in the presence of normal and abnormal mineral ion homeostasis. Prevention of abnormal mineral ion homeostasis resulted in the development of a normal skeleton in the absence of a functional vitamin D receptor. The metabolic cause of rickets was found to be hypophosphatemia. The major receptor-dependent actions of 1,25-dihydroxyvitamin D on skeletal development are indirect and are a reflection of the role of this hormone on intestinal calcium absorption.

引用

收藏

页码：S141 / S144

页数：4

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