Michael addition of amine derivatives to conjugate phosphinyl and phosphonyl nitrosoalkenes.: Preparation of α-amino phosphine oxide and phosphonate derivatives

被引：26

作者：

de los Santos, Jesus M. ^{[1
]}

Ignacio, Roberto ^{[1
]}

Aparicio, Domitila ^{[1
]}

Palacios, Francisco ^{[1
]}

机构：

[1] Univ Basque Country, Fac Farm, Dept Quim Organ I, Vitoria 01080, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 14期

关键词：

D O I：

10.1021/jo0705521

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of nitrosoalkenes derived from phosphine oxides and phosphonates generated through base-mediated dehydrohalogenations of readily available alpha-halooximes is reported. These highly reactive intermediates act as Michael acceptors toward nucleophilic reagents such as ammonia, amines, and optically active amino esters, furnishing alpha-amino phosphine oxides and phosphonates in a highly regioselective fashion.

引用

页码：5202 / 5206

页数：5

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