Medium chain triglycerides as vehicle for palatable oral liquids

被引：19

作者：

Bahal, SM ^{[1
]}

Romansky, JM ^{[1
]}

Alvarez, FJ ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res & Dev, Wilmington, DE USA

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2003年 / 8卷 / 01期

关键词：

medium-chain triglycerides; MCT; vehicle for pharmaceuticals; palatable oral liquids; masking the taste of drugs; efavirenz oral liquid;

D O I：

10.1081/PDT-120017518

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aqueous liquid formulations of efavirenz, a nonnucleoside inhibitor of reverse transcriptase, have prolonged burning (peppery) taste. Medium-chain triglycerides (MCT) was used as the vehicle to mask the taste and obtain palatable oral liquid formulations containing 20 mg/mL efavirenz. The use of MCT for enhancement of palatability and stability is recommended for drugs that show high solubility and partitioning in this vehicle.

引用

页码：111 / 115

页数：5