Convenient Electrophilic Fluorination of Functionalized Aryl and Heteroaryl Magnesium Reagents

被引：99
作者：
Yamada, Shigeyuki [1 ]
Gavryushin, Andrei [1 ]
Knochel, Paul [1 ]
机构：
[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 12期
基金：
欧洲研究理事会;
关键词：
arenes; electrophilic substitution; fluorination; Grignard reaction; nitrogen heterocycles; NUCLEOPHILIC-SUBSTITUTION; BORONIC ACIDS; TRIFLUOROMETHYLATION; ARYLMAGNESIUM; RADIOLIGAND; NUCLEOSIDES;
D O I：
10.1002/anie.200905052
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chemical Equation Presented" Cive me an "F": Electrophilic fluorination of various aromatic and heteroaromatic Grignard reagents is smoothly performed with (PhSO2)2NF as fluorinating agent in a 4:1 mixture of CH2Cl2/ perfluorodecalin (see scheme). This solvent system allows minimization of most side reactions. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA."
引用
收藏
页码：2215 / 2218
页数：4
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