Synthesis of novel 2-substituted-1,3,4-thiadiazoles

被引：0

作者：

Matsubara, Y ^{[1
]}

Kitano, K ^{[1
]}

Yamamoto, T ^{[1
]}

Maeshima, T ^{[1
]}

机构：

[1] Kinki Univ, Fac Sci & Engn, Dept Appl Chem, Osaka 577, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1998年 / 46卷 / 02期

关键词：

N '-phenylthiobenzoylhydrazide; intramolecular cyclization; anti-mildew; 2-substituted-2,3-dihydro-3,5-diphenyl-1,3,4-thiadiazole; wheat powdery mildew;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nem 2-monosubstituted and 2,2-disubstituted 2,3-dihydro-3,5-diphenyl-1,3,4-thiadiazoles (2) were synthesized by the reaction of N'-phenylthiobenzoylhydrazide with aliphatic, aromatic and heterocyclic aldehydes and ketones in the presence of trimethylsilyl chloride in benzene, The reaction proceeded smoothly to afford the corresponding 1,3,4-thiadiazoles (2a-2j) in excellent yields (84-96%) except for a few cases, such as the 5-methyl-2-furfural and 2-acetylthiophene systems, 2,3-Dihydro-2,2-dimethyl-3,5-diphenyl-1,3,4-thiazole (2f) showed curative activity against powdery mildew of wheat.

引用

页码：329 / 331

页数：3

共 6 条

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[5] THE SYNTHESIS AND STRUCTURE OF 3-PHENYL-1,3,4-THIADIAZOL-2(3H)-ONE [J].

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