On the C-2 epimerisation of kainoids

被引：8

作者：

Klotz, P ^{[1
]}

Mann, A ^{[1
]}

机构：

[1] Fac Pharm, Lab Pharmacochim Commun Cellulaire, UMR 7081, F-67401 Illkirch Graffenstaden, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(03)00077-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The conditions for the epimerisation at carbon C-2 of phenyl kainic acid esters 6 and 7 and cis-3-prolinoglutamic esters 10 were systematically addressed. We found that the use of KHMDS in THF gave improved results over the existing procedures. Some mechanistic aspects of this peculiar epimerisation are discussed. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1927 / 1930

页数：4

共 41 条

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