"Standing by" for Bystander Effects: Dual-Isotope Imaging of Antibody-Drug Conjugate and Payload Distribution

被引:4
作者
Cilliers, Cornelius [1 ]
Thurber, Greg M. [1 ,2 ]
机构
[1] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
关键词
PENETRATION;
D O I
10.2967/jnumed.118.213389
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
[No abstract available]
引用
收藏
页码:1459 / 1460
页数:2
相关论文
共 10 条
[1]   The Pharmacologic Basis for Antibody-Auristatin Conjugate Activity [J].
Alley, Stephen C. ;
Zhang, Xinqun ;
Okeley, Nicole M. ;
Anderson, Martha ;
Law, Che-Leung ;
Senter, Peter D. ;
Benjamin, Dennis R. .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2009, 330 (03) :932-938
[2]   Improved Tumor Penetration and Single-Cell Targeting of Antibody-Drug Conjugates Increases Anticancer Efficacy and Host Survival [J].
Cilliers, Cornelius ;
Menezes, Bruna ;
Nessler, Ian ;
Linderman, Jennifer ;
Thurber, Greg M. .
CANCER RESEARCH, 2018, 78 (03) :758-768
[3]   The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates [J].
Erickson, Hans K. ;
Phillips, Gail D. Lewis ;
Leipold, Douglas D. ;
Provenzano, Carmela A. ;
Mai, Elaine ;
Johnson, Holly A. ;
Gunter, Bert ;
Audette, Charlene A. ;
Gupta, Manish ;
Pinkas, Jan ;
Tibbitts, Jay .
MOLECULAR CANCER THERAPEUTICS, 2012, 11 (05) :1133-1142
[4]   Dual-Isotope Cryoimaging Quantitative Autoradiography: Investigating Antibody-Drug Conjugate Distribution and Payload Delivery Through Imaging [J].
Ilovich, Ohad ;
Qutaish, Mohammed ;
Hesterman, Jacob Y. ;
Orcutt, Kelly ;
Hoppin, Jack ;
Polyak, Ildiko ;
Seaman, Marc ;
Abu-Yousif, Adnan O. ;
Cvet, Donna ;
Bradley, Daniel P. .
JOURNAL OF NUCLEAR MEDICINE, 2018, 59 (09) :1461-1466
[5]   Computational transport analysis of antibody-drug conjugate bystander effects and payload tumoral distribution: implications for therapy [J].
Khera, Eshita ;
Cilliers, Cornelius ;
Bhatnagar, Sumit ;
Thurber, Greg M. .
MOLECULAR SYSTEMS DESIGN & ENGINEERING, 2018, 3 (01) :73-88
[6]   Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models [J].
Li, Fu ;
Emmerton, Kim K. ;
Jonas, Mechthild ;
Zhang, Xinqun ;
Miyamoto, Jamie B. ;
Setter, Jocelyn R. ;
Nicholas, Nicole D. ;
Okeley, Nicole M. ;
Lyon, Robert P. ;
Benjamin, Dennis R. ;
Law, Che-Leung .
CANCER RESEARCH, 2016, 76 (09) :2710-2719
[7]   A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity [J].
Miller, Michael L. ;
Fishkin, Nathan E. ;
Li, Wei ;
Whiteman, Kathleen R. ;
Kovtun, Yelena ;
Reid, Emily E. ;
Archer, Katie E. ;
Maloney, Erin K. ;
Audette, Charlene A. ;
Mayo, Michele F. ;
Wilhelm, Alan ;
Modafferi, Holly A. ;
Singh, Rajeeva ;
Pinkas, Jan ;
Goldmacher, Victor ;
Lambert, John M. ;
Chari, Ravi V. J. .
MOLECULAR CANCER THERAPEUTICS, 2016, 15 (08) :1870-1878
[8]   Drug penetration in solid tumours [J].
Minchinton, Andrew I. ;
Tannock, Ian F. .
NATURE REVIEWS CANCER, 2006, 6 (08) :583-592
[9]   Prediction of Drug Distribution in Subcutaneous Xenografts of Human Tumor Cell Lines and Healthy Tissues in Mouse: Application of the Tissue Composition-Based Model to Antineoplastic Drugs [J].
Poulin, Patrick ;
Chen, Yung-Hsiang ;
Ding, Xiao ;
Gould, Stephen E. ;
Hop, Cornelis Eca ;
Messick, Kirsten ;
Oeh, Jason ;
Liederer, Bianca M. .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 104 (04) :1508-1521
[10]   Quantitative characterization of in vitro bystander effect of antibody-drug conjugates [J].
Singh, Aman P. ;
Sharma, Sharad ;
Shah, Dhaval K. .
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2016, 43 (06) :567-582