Calmodulin: a prototypical calcium sensor

被引：1197

作者：

Chin, D ^{[1
]}

Means, AR ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

来源：

TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0962-8924(00)01800-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calmodulin is the best studied and prototypical example of the E-F-hand family of Ca2+-sensing proteins. Changes in intracellular Ca2+ concentration regulate calmodulin in three distinct ways. First at the cellular Level, by directing its subcellular distribution. Second, at the molecular level, by promoting different modes of association with many target proteins. Third, by directing a variety of conformational states in calmodulin that result in target-specific activation. The calmodulin-dependent regulation of protein kinases illustrates the potential mechanisms by which Ca2+-sensing proteins can recognize and generate affinity and specificity for effectors in a Ca2+-dependent manner.

引用

页码：322 / 328

页数：7

共 39 条

[1] LOCALIZED CALCIUM SPIKES AND PROPAGATING CALCIUM WAVES [J].

ALLBRITTON, NL ;

MEYER, T .

CELL CALCIUM, 1993, 14 (10) :691-697

[2] Intracellular neuronal calcium sensor proteins: a family of EF-hand calcium-binding proteins in search of a function [J].

Braunewell, KH ;

Gundelfinger, ED .

CELL AND TISSUE RESEARCH, 1999, 295 (01) :1-12

[3] Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I [J].

Chin, D ;

Winkler, KE ;

Means, AR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (50) :31235-31240

[4] Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface [J].

Chin, D ;

Sloan, DJ ;

Quiocho, FA ;

Means, AR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (09) :5510-5513

[5] Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases [J].

Chin, D ;

Means, AR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (48) :30465-30471

[6] Hormone-induced secretory and nuclear translocation of calmodulin:: Oscillations of calmodulin concentration with the nucleus as an integrator [J].

Craske, H ;

Takeo, T ;

Gerasimenko, O ;

Vaillant, C ;

Török, K ;

Petersen, OH ;

Tepikin, AV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (08) :4426-4431

[7] Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons [J].

Deisseroth, K ;

Heist, EK ;

Tsien, RW .

NATURE, 1998, 392 (6672) :198-202

[8] Calcium oscillations increase the efficiency and specificity of gene expression [J].

Dolmetsch, RE ;

Xu, KL ;

Lewis, RS .

NATURE, 1998, 392 (6679) :933-936

[9] NMR solution structure of a complex of calmodulin with a binding peptide of the Ca2+ pump [J].

Elshorst, B ;

Hennig, M ;

Försterling, H ;

Diener, A ;

Maurer, M ;

Schulte, P ;

Schwalbe, H ;

Griesinger, C ;

Krebs, J ;

Schmid, H ;

Vorherr, T ;

Carafoli, E .

BIOCHEMISTRY, 1999, 38 (38) :12320-12332

[10] CALCIUM SIGNALING IN NEURONS - MOLECULAR MECHANISMS AND CELLULAR CONSEQUENCES [J].

GHOSH, A ;

GREENBERG, ME .

SCIENCE, 1995, 268 (5208) :239-247

← 1 2 3 4 →