An early prediction of crop biomass at maturity and yield is important in different circumstances. The use of spectral reflectance indices, such as the Normalized Difference Vegetation Index (NDVI), has been proposed as a fast, nondestructive way of estimating crop growth capacity. In this study, we examined whether NDVI assessment relatively early in the crop cycle may be useful for predicting final biomass and yield in wheat. To that end, NDVI was measured and biomass quantified regularly from tillering to maturity for six different wheat genotypes grown under a contrasting range of N and water availabilities. In addition, final biomass and yield were measured at maturity. In line with expectations from the literature, we found that NDVI at milk-grain stage was well correlated to final yield and biomass. However, it was also observed that NDVI at the onset of stem elongation was also reasonably correlated to both attributes. Because crop growth in wheat from the end of tillering to anthesis is related to the determination of grain number and yield, we propose the use of NDVI at the onset of stem elongation as a complementary criterion for establishing the required late crop management ( N fertilisation, irrigation) practices.