Donor factors influencing graft outcomes in live donor kidney transplantation

被引:71
作者
Issa, Naim
Stephany, Brian
Fatica, Richard
Nurko, Saul
Krishnamurthi, Venkatesh
Goldfarb, David A.
Braun, William E.
Dennis, Vincent W.
Heeger, Peter S.
Poggio, Emilio D.
机构
[1] Cleveland Clin, Dept Hypertens & Nephrol, Cleveland, OH 44195 USA
[2] Cleveland Clin, Glickman Urol Inst, Cleveland, OH 44195 USA
[3] Cleveland Clin, Dept Immunol, Cleveland, OH 44195 USA
关键词
glomerular filtration rate; cholesterol; living donor; kidney transplantation; graft outcome; age; blood pressure;
D O I
10.1097/01.tp.0000256284.78721.ba
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Living donor renal allograft survival is superior to that achieved from deceased donors, although graft outcome is suboptimal in some of these patients. in an effort to identify the subset of patients at high risk for poor outcomes we studied donor risk factors in 248 living kidney donor-recipient pairs. Unadjusted donor I-121-iothalamate GFR (iGFR), donor age more than 45 years, donor total cholesterol level less than 200 mg/dL, and donor systolic blood pressure (SBP) less than 120 mm Hg were correlated with allograft estimated glomerular filtration rate (eGFR), and incidence of acute rejection (AR), delayed graft function and/or graft loss at 2 years posuransplantation. Donor iGFR less than 110 mL/min (slope= -7.40, P < 0.01), donors more than 45 years (slope= -8.76, P < 0.01), donor total cholesterol levels more than 200 mg/dL (slope=-10.03, P < 0.01), and SBP more than 120 mm Hg (slope=-5.60, P=0.03) were associated with lower eGFR. By multivariable linear regression analysis these variables remained independently associated with lower eGFR, and poorer outcomes. The increasing number of donor factors (age, iGFR, cholesterol, and blood pressure) was directly associated with worse posttransplant eGFR (P < 0.01). In conclusion, our data suggest that routine assessment of living donor parameters could supplement the consideration of recipient characteristics in predicting posttransplant risk of graft injury/dysfunction.
引用
收藏
页码:593 / 599
页数:7
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