Molecular Mechanisms and Targets of Therapy for Hepatocellular Carcinoma

被引：41

作者：

Klungboonkrong, Vivian ^{[1
,4
]}

Das, Dola ^{[2
,3
]}

McLennan, Gordon ^{[1
]}

机构：

[1] Cleveland Clin, Dept Intervent Radiol, 9500 Euclid Ave, Cleveland, OH 44195 USA

[2] Cleveland Clin, Imaging Inst, 9500 Euclid Ave, Cleveland, OH 44195 USA

[3] Cleveland Clin, Lerner Res Inst, 9500 Euclid Ave, Cleveland, OH 44195 USA

[4] KhonKaen Univ, Dept Radiol, Khon Kaen, Thailand

来源：

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY | 2017年 / 28卷 / 07期

关键词：

REGULATORY T-CELLS; GROWTH-HORMONE; HUMAN LIVER; TRANSFORMING GROWTH-FACTOR-BETA-1; MESENCHYMAL TRANSITION; SOMATOSTATIN RECEPTORS; ARTERIAL EMBOLIZATION; BINDING-PROTEINS; PROLIFERATION; CANCER;

D O I：

10.1016/j.jvir.2017.03.002

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. HCC develops through a multistep process that involves the local tumor microenvironment, intracellular signaling pathways, and altered metabolic system that allows the cancer proliferation. Understanding the mechanisms of tumor development and progression is critical to developing improved therapies aimed at better survival. This article reviews the molecular mechanisms of HCC development and highlights the potential therapeutic targets for treatments.

引用

页码：949 / 955

页数：7

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