The synthesis of azabicyclic heterocycles

被引：5
|
作者：
Darout, Etzer [1 ]
Basak, Arindrajit [1 ]
机构：
[1] Groton Labs, Pfizer Global Res & Dev, Groton, CT 06340 USA
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 22期
关键词：
KETONES;
D O I：
10.1016/j.tetlet.2010.03.123
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient approach to a oxa-azabicyclo[3.2.1] derivatives has been achieved via a double-Mannich reaction of N,N-bis(methoxymethyl)-1-phenylethanamine with symmetrical and unsymmetrical ketones. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2998 / 3001
页数：4
相关论文
共 50 条
  • [1] Synthesis and Biological Evaluation of a New Family of Constrained Azabicyclic Homocholine Analogues
    Halliday, Jill I.
    Chebib, Mary
    McLeod, Malcolm D.
    AUSTRALIAN JOURNAL OF CHEMISTRY, 2010, 63 (05) : 808 - 812
  • [2] Xylochemical synthesis of diarylated heterocycles
    Millar, Stephanie B.
    Khachatryan, Hasmik N.
    Malmir, Masoume
    Sperry, Jonathan
    SUSTAINABLE CHEMISTRY AND PHARMACY, 2024, 42
  • [3] Synthesis of new, paramagnetically modified heterocycles
    Tamas Kalai
    Balazs Bognar
    Jozsef Jeko
    Kalman Hideg
    SYNTHESIS-STUTTGART, 2006, (15): : 2573 - 2579
  • [4] A General Method for the Enantioselective Synthesis of α-Chiral Heterocycles
    Le, Phong Q.
    Nguyen, Thien S.
    May, Jeremy A.
    ORGANIC LETTERS, 2012, 14 (23) : 6104 - 6107
  • [5] Copper in Efficient Synthesis of Aromatic Heterocycles with Single Heteroatom
    Pal, Tapas
    Lahiri, Goutam Kumar
    Maiti, Debabrata
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 2020 (44) : 6859 - 6869
  • [6] A Bioinspired Strategy for the Enantioselective Synthesis of Bicyclic Oxygen Heterocycles
    Venegas, Edith Rodriguez
    Willis, Christine L.
    ORGANIC LETTERS, 2020, 22 (07) : 2548 - 2552
  • [7] Pyrazolones as versatile precursors for the synthesis of fused and binary heterocycles
    Hamama, WS
    SYNTHETIC COMMUNICATIONS, 2001, 31 (09) : 1335 - 1345
  • [8] Synthesis of Azabicyclic Building Blocks for Daphniphyllum Alkaloid Intermediates Featuring N-Trichloroacetyl Enamide 5-endo-trig Radical Cyclizations
    Jansana, Sergi
    Coussanes, Guilhem
    Puig, Jordi
    Diaba, Faiza
    Bonjoch, Josep
    HELVETICA CHIMICA ACTA, 2019, 102 (10)
  • [9] The Chemistry of Aldehydes and Ketones in the Synthesis of Heterocycles - Historical Reactions with a New and Green Perspective
    da Silva, Flavia Martins
    Jones Junior, Joel
    Hernandez Munoz, July A.
    CURRENT ORGANIC CHEMISTRY, 2024, 28 (13) : 1023 - 1045
  • [10] Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles
    Potukuchi, Harish K.
    Spork, Anatol P.
    Donohoe, Timothy J.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (15) : 4367 - 4373
12345