Rheumatoid Arthritis Complicated with Nasal Septum Perforation Due to Methotrexate-associated Lymphoproliferative Disorder

被引：4
作者：
Sakaguchi, Ryuki [1 ]
Fujikawa, Keita [1 ]
Okamoto, Momoko [1 ]
Matsuo, Emi [2 ]
Matsumoto, Kohei [3 ]
Uchida, Tomohisa [1 ]
Shin-ya, Kawashiri [4 ]
Nakashima, Masahiro [5 ]
Mizokami, Akinari [1 ]
Kawakami, Atsushi [4 ]
机构：
[1] Isahaya Gen Hosp, Dept Rheumatol, Japan Community Healthcare Org, Isahaya, Japan
[2] Isahaya Gen Hosp, Dept Hematol, Japan Community Healthcare Org, Isahaya, Japan
[3] Isahaya Gen Hosp, Dept Otolaryngol, Japan Community Healthcare Org, Isahaya, Japan
[4] Nagasaki Univ, Grad Sch Biomed Sci, Dept Immunol & Rheumatol, Nagasaki, Japan
[5] Nagasaki Univ, Atom Bomb Dis Inst, Dept Tumor & Diagnost Pathol, Nagasaki, Japan
来源：
INTERNAL MEDICINE | 2019年 / 58卷 / 21期
关键词：
nasal septum perforation; methotrexate-associated lymphoproliferative disorder; peripheral T-cell lymphoma; rheumatoid arthritis; EPSTEIN-BARR-VIRUS; VASCULITIS; LYMPHOMA; PATIENT;
D O I：
10.2169/internalmedicine.2995-19
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 44-year-old female with rheumatoid arthritis treated with methotrexate (MTX) and tocilizumab (TCZ) was admitted to our hospital with nasal pain. Nasal fiberscopy revealed septum perforation, while a membrane biopsy indicated granuloma and fibrinoid necrosis of the small artery. The patient was treated with prednisolone 30 mg/day after discontinuation of MTX and TCZ. Inguinal lymph node biopsy revealed diffuse infiltrations of atypical T-cells and Epstein-Barr virus-positive B cells. The patient was diagnosed with peripheral T-cell lymphoma due to MTX-associated lymphoproliferative disorder (MTX-LPD). We herein describe the case of a patient with nasal septum perforation due to MTX-LPD mimicking granulomatosis with polyangiitis.
引用
收藏
页码：3167 / 3171
页数：5
相关论文
共 50 条
  • [31] A case of multiple hepatic lesions associated with methotrexate-associated lymphoproliferative disorder
    Ruby Matsumoto
    Kazushi Numata
    Nobutaka Doba
    Koji Hara
    Makoto Chuma
    Hiroyuki Fukuda
    Akito Nozaki
    Katsuaki Tanaka
    Yoshimi Ishii
    Shin Maeda
    Journal of Medical Ultrasonics, 2016, 43 : 545 - 551
  • [32] A Case of Methotrexate-Associated Lymphoproliferative Disorder (Lymphomatoid Granulomatosis) of the Skin
    Nishida, Haruto
    Oyama, Yuzo
    Kusaba, Takahiro
    Kadowaki, Hiroko
    Arakane, Motoki
    Yokoyama, Shigeo
    Hatano, Yutaka
    Daa, Tsutomu
    AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2019, 41 (06) : 448 - 452
  • [33] Methotrexate-Associated Lymphoproliferative Disorder with Intraocular Involvement Improved with Intravitreal Methotrexate and Chemotherapy: A Case Report
    Yamasaki, Atsushi
    Hoshi, Futoshi
    Yamada, Fusae
    Tamaru, Jun-Ichi
    Tokuhira, Michihide
    Obata, Hiroto
    CASE REPORTS IN OPHTHALMOLOGY, 2024, 15 (01): : 807 - 814
  • [34] Methotrexate-associated lymphoproliferative disorders of the tongue developing in patients with rheumatoid arthritis: a report of 2 cases and a review
    Hashimoto, Kengo
    Nagao, Toru
    Saito, Terumi
    Kinoshita, Hiroyuki
    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 2015, 119 (01): : E1 - E5
  • [35] Methotrexate-Associated Lymphoproliferative Disorder Mimicking Composite Lymphoma
    Jun-ichiro Ikeda
    Eiichi Morii
    Yasuhiko Tomita
    Jing-Xian Xu
    Hayato Kimura
    Masaharu Kohara
    Yoshihiko Hoshida
    Katsuyuki Aozasa
    International Journal of Hematology, 2006, 83 : 363 - 365
  • [36] Cessation of methotrexate and a small intestinal resection provide a good clinical course for a patient with a jejunum perforation induced by a methotrexate-associated lymphoproliferative disorder: a case report
    Nomura, Masahiro
    Sumiya, Ryusuke
    Ono, Hayato
    Nagai, Takeshi
    Kumazawa, Keigo
    Shimizu, Atsushi
    Endo, Daisuke
    Aoyanagi, Nobuyoshi
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2021, 19 (01)
  • [37] Methotrexate-associated lymphoproliferative disorder affecting the gingiva and intestinal mucosa with intestinal perforation: A case report
    Fujinaga, Takahiro
    Ohyama, Yukiko
    Nagano, Koki
    Imajo, Ikumi
    Yamada, Tomohiro
    Kiyoshima, Tamotsu
    Mori, Yoshihide
    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 2022, 34 (02) : 169 - 173
  • [38] Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma
    Ishigaki, Sho
    Masaoka, Tatsuhiro
    Kameyama, Hisako
    Kawaida, Miho
    Kameyama, Kaori
    Mori, Takehiko
    Kanai, Takanori
    INTERNAL MEDICINE, 2018, 57 (22) : 3249 - 3254
  • [39] A case of T-cell dominant polymorphic methotrexate-associated lymphoproliferative disorder with peri-implantitis
    Sekido, Katsuhisa
    Asakura, Minami
    Tachinami, Hidetake
    Noguchi, Makoto
    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 2024, 36 (01) : 47 - 51
  • [40] Methotrexate-associated Lymphoproliferative Disorder in the Liver Resembling Hepatocellular Carcinoma Treated with Transarterial Chemoembolization
    Tsuruoka, Mio
    Inoue, Jun
    Kakazu, Eiji
    Ninomiya, Masashi
    Iwata, Tomoaki
    Sano, Akitoshi
    Masamune, Atsushi
    INTERNAL MEDICINE, 2020, 59 (18) : 2255 - 2260
12345