Rheumatoid Arthritis Complicated with Nasal Septum Perforation Due to Methotrexate-associated Lymphoproliferative Disorder

被引：4

作者：

Sakaguchi, Ryuki ^{[1
]}

Fujikawa, Keita ^{[1
]}

Okamoto, Momoko ^{[1
]}

Matsuo, Emi ^{[2
]}

Matsumoto, Kohei ^{[3
]}

Uchida, Tomohisa ^{[1
]}

Shin-ya, Kawashiri ^{[4
]}

Nakashima, Masahiro ^{[5
]}

Mizokami, Akinari ^{[1
]}

Kawakami, Atsushi ^{[4
]}

机构：

[1] Isahaya Gen Hosp, Dept Rheumatol, Japan Community Healthcare Org, Isahaya, Japan

[2] Isahaya Gen Hosp, Dept Hematol, Japan Community Healthcare Org, Isahaya, Japan

[3] Isahaya Gen Hosp, Dept Otolaryngol, Japan Community Healthcare Org, Isahaya, Japan

[4] Nagasaki Univ, Grad Sch Biomed Sci, Dept Immunol & Rheumatol, Nagasaki, Japan

[5] Nagasaki Univ, Atom Bomb Dis Inst, Dept Tumor & Diagnost Pathol, Nagasaki, Japan

来源：

INTERNAL MEDICINE | 2019年 / 58卷 / 21期

关键词：

nasal septum perforation; methotrexate-associated lymphoproliferative disorder; peripheral T-cell lymphoma; rheumatoid arthritis; EPSTEIN-BARR-VIRUS; VASCULITIS; LYMPHOMA; PATIENT;

D O I：

10.2169/internalmedicine.2995-19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 44-year-old female with rheumatoid arthritis treated with methotrexate (MTX) and tocilizumab (TCZ) was admitted to our hospital with nasal pain. Nasal fiberscopy revealed septum perforation, while a membrane biopsy indicated granuloma and fibrinoid necrosis of the small artery. The patient was treated with prednisolone 30 mg/day after discontinuation of MTX and TCZ. Inguinal lymph node biopsy revealed diffuse infiltrations of atypical T-cells and Epstein-Barr virus-positive B cells. The patient was diagnosed with peripheral T-cell lymphoma due to MTX-associated lymphoproliferative disorder (MTX-LPD). We herein describe the case of a patient with nasal septum perforation due to MTX-LPD mimicking granulomatosis with polyangiitis.

引用

页码：3167 / 3171

页数：5

共 17 条

[11] Prognostic factors of methotrexate-associated lymphoproliferative disorders associated with rheumatoid arthritis and plausible application of biological agents [J].

Katsuyama, Takayuki ;

Sada, Ken-Ei ;

Yan, Minglu ;

Zeggar, Sonia ;

Hiramatsu, Sumie ;

Miyawaki, Yoshia ;

Ohashi, Keiji ;

Morishita, Michiko ;

Watanabe, Haruki ;

Katsuyama, Eri ;

Takano-Narazaki, Mariko ;

Toyota-Tatebe, Noriko ;

Sunahori-Watanabe, Katsue ;

Kawabata, Tomoko ;

Miyake, Kohei ;

Kiguchi, Toru ;

Wada, Jun .

MODERN RHEUMATOLOGY, 2017, 27 (05) :773-777

[12] Risk of Malignancies in Patients With Rheumatoid Arthritis Treated With Biologic Therapy A Meta-analysis [J].

Lopez-Olivo, Maria A. ;

Tayar, Jean H. ;

Martinez-Lopez, Juan A. ;

Pollono, Eduardo N. ;

Polo Cueto, Jose ;

Rosa Gonzales-Crespo, M. ;

Fulton, Stephanie ;

Suarez-Almazor, Maria E. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 308 (09) :898-908

[13] Monitoring of Epstein-Barr virus (EBV)/cytomegalovirus (CMV)/varicella-zoster virus (VZV) load in patients receiving tocilizumab for rheumatoid arthritis [J].

Mourgues, Cindy ;

Henquell, Cecile ;

Tatar, Zuzana ;

Pereira, Bruno ;

Nourisson, Cinthya ;

Tournadre, Anne ;

Soubrier, Martin ;

Couderc, Marion .

JOINT BONE SPINE, 2016, 83 (04) :412-415

[14] Exacerbation of chronic active Epstein-Barr virus infection in a patient with rheumatoid arthritis receiving humanised anti-interleukin-6 receptor monoclonal antibody [J].

Ogawa, J. ;

Harigai, M. ;

Akashi, T. ;

Nagasaka, K. ;

Suzuki, F. ;

Tominaga, S. ;

Miyasaka, N. .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (12) :1667-1669

[15] Distinct patterns of lymphocyte count transition in lymphoproliferative disorder in patients with rheumatoid arthritis treated with methotrexate [J].

Saito, Shuntaro ;

Kaneko, Yuko ;

Yamaoka, Kunihiro ;

Tokuhira, Michihide ;

Takeuchi, Tsutomu .

RHEUMATOLOGY, 2017, 56 (06) :940-946

[16] Clinicopathological analyses in patients with other iatrogenic immunodeficiency-associated lymphoproliferative diseases and rheumatoid arthritis [J].

Tokuhira, Michihide ;

Watanabe, Reiko ;

Nemoto, Tomoe ;

Sagawa, Morihiko ;

Tomikawa, Tatsuki ;

Tamaru, Jun-ichi ;

Itoyama, Shinji ;

Nagasawa, Hayato ;

Amano, Koichi ;

Kameda, Hideto ;

Takeuchi, Tsutomu ;

Mori, Shigehisa ;

Kizaki, Masahiro .

LEUKEMIA & LYMPHOMA, 2012, 53 (04) :616-623

[17] Vasculitis and lymphoproliferative diseases [J].

Wooten, MD ;

Jasin, HE .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 1996, 26 (02) :564-574

← 1 2 →