Diagnosis and management of acute liver failure

被引：30
作者：
Larson, Anne M. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA
来源：
CURRENT OPINION IN GASTROENTEROLOGY | 2010年 / 26卷 / 03期
关键词：
acetaminophen; acute liver failure; encephalopathy; liver transplantation; INFLAMMATORY RESPONSE SYNDROME; ARTERIAL AMMONIA; CEREBRAL EDEMA; INTRACRANIAL HYPERTENSION; HEPATIC-ENCEPHALOPATHY; CONTROLLED-TRIAL; SERUM PHOSPHATE; EARLY PREDICTOR; BLOOD LACTATE; ACETAMINOPHEN;
D O I：
10.1097/MOG.0b013e32833847c5
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Purpose of review Acute liver failure (ALF) is a devastating syndrome afflicting previously healthy individuals. Early recognition of the illness is crucial, as aggressive treatment may improve outcomes. Despite significant advances in care, however, the mortality remains high (30-100%). This brief review will focus on the causes and overall management of the complications of ALF. Recent findings Our knowledge of the causes of ALF has expanded significantly in the last decade. The mechanism of hepatic encephalopathy and cerebral edema in this setting continues to be elucidated and is discussed here. Summary Improved outcomes can be achieved with the early recognition and aggressive management of ALF.
引用
收藏
页码：214 / 221
页数：8
相关论文
共 66 条
[1]   Characteristics of minimal hepatic encephalopathy [J].
Amodio, P ;
Montagnese, S ;
Gatta, A ;
Morgan, MY .
METABOLIC BRAIN DISEASE, 2004, 19 (3-4) :253-267
[2]   Fulminant hepatic failure secondary to acetaminophen poisoning: A systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation [J].
Bailey, B ;
Amre, DK ;
Gaudreault, P .
CRITICAL CARE MEDICINE, 2003, 31 (01) :299-305
[3]   Monitoring and treatment of intracranial hypertension [J].
Bass, NM .
LIVER TRANSPLANTATION, 2000, 6 (04) :S21-S26
[4]   Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study [J].
Bernal, W ;
Donaldson, N ;
Wyncoll, D ;
Wendon, J .
LANCET, 2002, 359 (9306) :558-563
[5]   Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure [J].
Bernal, William ;
Hall, Catherine ;
Karvellas, Constantine J. ;
Auzinger, Georg ;
Sizer, Elizabeth ;
Wendon, Juba .
HEPATOLOGY, 2007, 46 (06) :1844-1852
[6]  
Bernuau Jacques, 2006, Hepatology, V44, P502, DOI 10.1002/hep.21243
[7]   Predictive value of arterial ammonia for complications and outcome in acute liver failure [J].
Bhatia, V ;
Singh, R ;
Acharya, SK .
GUT, 2006, 55 (01) :98-104
[8]   Hypoxic hepatopathy: Pathophysiology and prognosis [J].
Birrer, Richard ;
Takuda, Yasuharu ;
Takara, Tsuyoshi .
INTERNAL MEDICINE, 2007, 46 (14) :1063-1070
[9]   The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema [J].
Bjerring, Peter Nissen ;
Eefsen, Martin ;
Hansen, Bent Adel ;
Larsen, Fin Stolze .
METABOLIC BRAIN DISEASE, 2009, 24 (01) :5-14
[10]   Population-based surveillance for acute liver failure [J].
Bower, William A. ;
Johns, Matthew ;
Margolis, Harold S. ;
Williams, Ian T. ;
Bell, Beth P. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2007, 102 (11) :2459-2463
1234567