Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

被引：198

作者：

Sherborne, Amy L. ^{[1
]}

Hosking, Fay J. ^{[1
]}

Prasad, Rashmi B. ^{[2
]}

Kumar, Rajiv ^{[2
]}

Koehler, Rolf ^{[3
]}

Vijayakrishnan, Jayaram ^{[1
]}

Papaemmanuil, Elli ^{[1
]}

Bartram, Claus R. ^{[3
]}

Stanulla, Martin ^{[4
]}

Schrappe, Martin ^{[4
]}

Gast, Andreas ^{[2
]}

Dobbins, Sara E. ^{[1
]}

Ma, Yussanne ^{[1
]}

Sheridan, Eamonn ^{[5
]}

Taylor, Malcolm ^{[6
]}

Kinsey, Sally E. ^{[7
]}

Lightfoot, Tracey ^{[8
]}

Roman, Eve ^{[8
]}

Irving, Julie A. E. ^{[9
]}

Allan, James M. ^{[9
]}

Moorman, Anthony V. ^{[9
]}

Harrison, Christine J. ^{[9
]}

Tomlinson, Ian P. ^{[10
]}

Richards, Sue ^{[11
,12
]}

Zimmermann, Martin ^{[13
]}

Szalai, Csaba ^{[14
]}

Semsei, Agnes F. ^{[14
]}

Erdelyi, Daniel J. ^{[14
]}

Krajinovic, Maja ^{[15
]}

Sinnett, Daniel ^{[15
]}

Healy, Jasmine ^{[15
]}

Gonzalez Neira, Anna ^{[16
]}

Kawamata, Norihiko ^{[17
]}

Ogawa, Seishi ^{[18
]}

Koeffler, H. Phillip ^{[19
]}

Hemminki, Kari ^{[2
]}

Greaves, Mel ^{[20
]}

Houlston, Richard S. ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton, Surrey, England

[2] German Canc Res Ctr, Div Mol Genet Epidemiol, D-6900 Heidelberg, Germany

[3] Heidelberg Univ, Inst Human Genet, Heidelberg, Germany

[4] Univ Kiel, Dept Pediat, Acute Lymphoblast Leukemia Berlin Frankfurt Munst, D-2300 Kiel, Germany

[5] St James Univ Hosp, Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England

[6] Univ Manchester, St Marys Hosp, Sch Canc Sci, Canc Immunogenet Grp, Manchester M13 0JH, Lancs, England

[7] St James Univ Hosp, Dept Paediat & Adolescent Oncol & Haematol, Leeds, W Yorkshire, England

[8] Univ York, Dept Hlth Sci, Epidemiol & Genet Unit, York YO10 5DD, N Yorkshire, England

[9] Newcastle Univ, No Inst Canc Res, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[10] Wellcome Trust Ctr Human Genet, Oxford, England

[11] Radcliffe Infirm, Clin Trial Serv Unit, Oxford OX2 6HE, England

[12] Epidemiol Studies Unit, Oxford, England

[13] Hannover Med Sch, Dept Pediat Hematol & Oncol, D-3000 Hannover, Germany

[14] Semmelweis Univ, SNP Core Facil Lab, Dept Genet Cell & Immunobiol, H-1085 Budapest, Hungary

[15] Univ Montreal, St Justine Univ Hlth Ctr, Res Ctr, Div Hematol Oncol, Montreal, PQ, Canada

[16] Spanish Natl Canc Res Ctr CNIO, Madrid, Spain

[17] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA

[18] Univ Tokyo, Sch Med, Tokyo 113, Japan

[19] Natl Univ Singapore, Inst Human Genet, Singapore 117548, Singapore

[20] Inst Canc Res, Sect Haematooncol, Sutton, Surrey, England

来源：

NATURE GENETICS | 2010年 / 42卷 / 06期

基金：

匈牙利科学研究基金会;

关键词：

GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY; VARIANTS; LOCI;

D O I：

10.1038/ng.585

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.

引用

页码：492 / 494

页数：3

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