Synthesis of pH-Responsive Multilayer Micelles for Sustained Release of Folic Acid

被引：0
作者：
Zhai, Cuiping [1 ]
Wang, Pan [1 ]
Liu, Xuejun [1 ]
机构：
[1] Henan Univ, Inst Fine Chem & Engn, Kaifeng 475004, Henan, Peoples R China
来源：
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2016年 / 55卷 / 08期
关键词：
Copolymers; drug delivery; micelles; pH-responsive; synthesis; METHOXY POLY(ETHYLENE GLYCOL); TRANSFER RAFT POLYMERIZATION; DRUG CARRIERS; NANOPARTICLES; DELIVERY; COPOLYMER; HYDROGELS; STRATEGY; BEHAVIOR;
D O I：
10.1080/03602559.2015.1132443
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Two novel triblock copolymers poly(hydroxypropyl acrylate)-b-poly (methyl methacrylate)-b-poly(N,N-dimethylaminoethyl methacrylate) and poly(hydroxypropyl acrylate)-b-poly(methyl methacrylate)-b-poly(acrylic acid) were successfully synthesized. In acetone media, using the electrostatic interactions between N,N-dimethylaminoethyl methacrylate and acrylic acid units, they could form spherically shaped multilayer micelles with pH-responsive, and have a mean diameter around 110nm. The critical micelle concentration of it was determined to be 2.42mg/L. In vitro release experiments, the folic acid-loaded micelles exhibited sustained release behavior and the drug release rate was affected by the pH value of release media. These results indicate that the multilayer micelles may serve as a novel intelligent drug delivery system. [GRAPHICS] .
引用
收藏
页码：818 / 825
页数：8
相关论文
共 26 条
  • [1] Poly(methyl methacrylate) particulate carriers in drug delivery
    Bettencourt, Ana
    Almeida, Antonio J.
    [J]. JOURNAL OF MICROENCAPSULATION, 2012, 29 (04) : 353 - 367
  • [2] Synthesis and characterization of polyion complex micelles between poly(ethylene glycol)-grafted poly(aspartic acid) and cetyltrimethyl ammonium bromide
    Chen, W
    Chen, HR
    Hu, JH
    Yang, WL
    Wang, CC
    [J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2006, 278 (1-3) : 60 - 66
  • [3] Formation and catalytic activity of spherical composites with surfaces coated with gold nanoparticles
    Chen, Xi
    Zhao, Dongyun
    An, Yingli
    Zhang, Yan
    Cheng, Jing
    Wang, Beilei
    Shi, Linqi
    [J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2008, 322 (02) : 414 - 420
  • [4] Thiocarbonylthio compounds [S=C(Ph)S-R] in free radical polymerization with reversible addition-fragmentation chain transfer (RAFT polymerization). Role of the free-radical leaving group (R)
    Chong, YK
    Krstina, J
    Le, TPT
    Moad, G
    Postma, A
    Rizzardo, E
    Thang, SH
    [J]. MACROMOLECULES, 2003, 36 (07) : 2256 - 2272
  • [5] Star-shaped poly(L-lactide)-b-poly(ethylene glycol) with porphyrin core: synthesis, self-assembly, drug-release behavior and singlet oxygen research
    Dai, Xiao-Hui
    Wang, Zhi-Ming
    Gao, Lu-You
    Pan, Jian-Ming
    Wang, Xiao-Hong
    Yan, Yong-Sheng
    Liu, Dong-Ming
    [J]. NEW JOURNAL OF CHEMISTRY, 2014, 38 (08) : 3569 - 3578
  • [6] Radical copolymerization of maleic anhydride and substituted styrenes by reversible addition-fragmentation chain transfer (RAFT) polymerization
    Davies, MC
    Dawkins, JV
    Hourston, DJ
    [J]. POLYMER, 2005, 46 (06) : 1739 - 1753
  • [7] Synthesis and characterization of a novel temperature-pH responsive copolymer of 2-hydroxypropyl acrylate and aminoethyl methacrylate hydrochloric salt
    Deng, K. L.
    Tian, H.
    Zhang, P. F.
    Ren, X. B.
    Zhong, H. B.
    [J]. EXPRESS POLYMER LETTERS, 2009, 3 (02): : 97 - 104
  • [8] Self-assembled biodegradable amphiphilic PEG-PCL-lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery
    Endres, Thomas K.
    Beck-Broichsitter, Moritz
    Samsonova, Olga
    Renette, Thomas
    Kissel, Thomas H.
    [J]. BIOMATERIALS, 2011, 32 (30) : 7721 - 7731
  • [9] Aqueous Self-Assembly of Giant Bottlebrush Block Copolymer Surfactants as Shape-Tunable Building Blocks
    Fenyves, Ryan
    Schmutz, Marc
    Horner, Ian J.
    Bright, Frank V.
    Rzayev, Javid
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (21) : 7762 - 7770
  • [10] Synthesis and swelling behavior of poly(2-dimethylaminoethyl methacrylate-co-N-hydroxymethyl acrylamide) hydrogels
    Gurdag, Gulten
    Cavus, Selva
    [J]. POLYMERS FOR ADVANCED TECHNOLOGIES, 2006, 17 (11-12) : 878 - 883
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