Synthesis of pH-Responsive Multilayer Micelles for Sustained Release of Folic Acid

被引：0

作者：

Zhai, Cuiping ^{[1
]}

Wang, Pan ^{[1
]}

Liu, Xuejun ^{[1
]}

机构：

[1] Henan Univ, Inst Fine Chem & Engn, Kaifeng 475004, Henan, Peoples R China

来源：

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2016年 / 55卷 / 08期

关键词：

Copolymers; drug delivery; micelles; pH-responsive; synthesis; METHOXY POLY(ETHYLENE GLYCOL); TRANSFER RAFT POLYMERIZATION; DRUG CARRIERS; NANOPARTICLES; DELIVERY; COPOLYMER; HYDROGELS; STRATEGY; BEHAVIOR;

D O I：

10.1080/03602559.2015.1132443

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Two novel triblock copolymers poly(hydroxypropyl acrylate)-b-poly (methyl methacrylate)-b-poly(N,N-dimethylaminoethyl methacrylate) and poly(hydroxypropyl acrylate)-b-poly(methyl methacrylate)-b-poly(acrylic acid) were successfully synthesized. In acetone media, using the electrostatic interactions between N,N-dimethylaminoethyl methacrylate and acrylic acid units, they could form spherically shaped multilayer micelles with pH-responsive, and have a mean diameter around 110nm. The critical micelle concentration of it was determined to be 2.42mg/L. In vitro release experiments, the folic acid-loaded micelles exhibited sustained release behavior and the drug release rate was affected by the pH value of release media. These results indicate that the multilayer micelles may serve as a novel intelligent drug delivery system. [GRAPHICS] .

引用

页码：818 / 825

页数：8

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