Poly (ADP-ribose) polymerase-1 (PARP-1) genetic variants are protective against Parkinson's disease

被引：26

作者：

Infante, Jon ^{[1
]}

Sanchez-Juan, Pascual

Mateo, Ignacio

Rodriguez-Rodriguez, Eloy

Sanchez-Quintana, Coro

Llorca, Javier

Fontalba, Ana

Terrazas, Jesus

Oterino, Agustin

Berciano, Jose

Combarros, Onofre

机构：

[1] Univ Cantabria, Univ Hosp Marques Valdecilla, Neurol Serv, Santander 39008, Spain

[2] Univ Cantabria, Sch Med, Div Prevent Med, Santander 39008, Spain

[3] Univ Hosp Marques Valdecilla, Unit Mol Genet, Santander 39008, Spain

[4] Laredo Hosp, Neurol Serv, Laredo, Spain

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2007年 / 256卷 / 1-2期

关键词：

poly (ADP-ribose) polymerase-1; PARP-1; Parkinson's disease; alpha-synuclein; oxidative stress;

D O I：

10.1016/j.jns.2007.02.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter variations of PARP-1 gene on the risk for PD in a case-control association study comprising 146 PD patients and 161 controls from Northern Spain. Three polymorphisms from the promoter region of PARP-1 gene were analyzed: -410C/T, -1672G/A, and a (CA)n microsatellite. A protective effect against PD was found for heterozygosity at (-410) (OR 0.44) and (CA)n microsatellite (OR 0.53) polymorphisms, and heterozygosity at (-1672) polymorphism delayed by 4 years on the onset age of PD. Variations in the regulatory region of PARP-1 gene might modify the risk for PD. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：68 / 70

页数：3

共 11 条

[1] Poly(ADP-ribose) polymerase-1 activity promotes NF-κB-driven transcription and microglial activation:: implication for neurodegenerative disorders [J].

Chiarugi, A ;

Moskowitz, MA .

JOURNAL OF NEUROCHEMISTRY, 2003, 85 (02) :306-317

[2] Regulation of α-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene [J].

Chiba-Falek, O ;

Kowalak, JA ;

Smulson, ME ;

Nussbaum, RL .

AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (03) :478-492

[3] Molecular heterosis: A review [J].

Comings, DE ;

MacMurray, JP .

MOLECULAR GENETICS AND METABOLISM, 2000, 71 (1-2) :19-31

[4] DINUCLEOTIDE REPEAT POLYMORPHISM AT THE HUMAN POLY (ADP-RIBOSE) POLYMERASE GENE (PPOL) [J].

FOUGEROUSSE, F ;

MELONI, R ;

ROUDAUT, C ;

BECKMANN, JS .

NUCLEIC ACIDS RESEARCH, 1992, 20 (05) :1166-1166

[5]

Gandhi S, 2005, HUM MOL GENET, V14, P2749, DOI 10.1093/hmg/ddi308

[6] ACCURACY IN THE CLINICAL-DIAGNOSIS OF PARKINSONIAN SYNDROMES [J].

GIBB, WRG .

POSTGRADUATE MEDICAL JOURNAL, 1988, 64 (751) :345-351

[7] A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice [J].

Iwashita, A ;

Mihara, K ;

Yamazaki, S ;

Matsuura, S ;

Ishida, J ;

Yamamoto, H ;

Hattori, K ;

Matsuoka, N ;

Mutoh, S .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 310 (03) :1114-1124

[8] Evaluation of the poly(ADP-ribose) polymerase gene in human stroke [J].

Kato, N ;

Morita, H ;

Sugiyama, T ;

Kurihara, H ;

Tsubaki, S ;

Nabika, T ;

Kitamura, K ;

Yamori, Y ;

Yazaki, Y .

ATHEROSCLEROSIS, 2000, 148 (02) :345-352

[9] Poly(ADP-ribosyl)ation regulation of life and death in the nervous system [J].

Koh, DW ;

Dawson, TM ;

Dawson, VL .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2005, 62 (7-8) :760-768

[10] The expression of PARP, NF-κB and parvalbumin is increased in Parkinson disease [J].

Soós, J ;

Engelhardt, JI ;

Siklós, L ;

Havas, L ;

Majtényi, K .

NEUROREPORT, 2004, 15 (11) :1715-1718

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