Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials

被引：91

作者：

Iwatsubo, Takeshi ^{[1
,2
]}

Iwata, Atsushi ^{[3
]}

Suzuki, Kazushi ^{[1
]}

Ihara, Ryoko ^{[1
]}

Arai, Hiroyuki ^{[4
]}

Ishii, Kenji ^{[5
]}

Senda, Michio ^{[6
]}

Ito, Kengo ^{[7
]}

Ikeuchi, Takeshi ^{[8
]}

Kuwano, Ryozo ^{[8
]}

Matsuda, Hiroshi ^{[9
]}

Sun, Chung-Kai ^{[10
]}

Beckett, Laurel A. ^{[11
]}

Petersen, Ronald C. ^{[12
]}

Weiner, Michael W. ^{[13
]}

Aisen, Paul S. ^{[10
]}

Donohue, Michael C. ^{[10
]}

机构：

[1] Univ Tokyo Hosp, Unit Early & Exploratory Clin Dev, Tokyo, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Neuropathol, Tokyo, Japan

[3] Univ Tokyo Hosp, Dept Neurol, Tokyo, Japan

[4] Tohoku Univ, Dept Geriatr, Sendai, Miyagi, Japan

[5] Tokyo Metropolitan Inst Gerontol, Res Team Neuroimaging, Tokyo, Japan

[6] Inst Biomed Res & Innovat, Div Mol Imaging, Kobe, Hyogo, Japan

[7] Natl Ctr Geriatr & Gerontol, Dept Clin & Expt Neuroimaging, Obu, Japan

[8] Niigata Univ, Ctr Bioresources, Brain Res Inst, Dept Mol Genet,Bioresource Sci Branch, Niigata, Japan

[9] Natl Ctr Neurol & Psychiat, Integrat Brain Imaging Ctr, Kodaira, Tokyo, Japan

[10] Univ Southern Calif, Alzheimers Therapeut Res Inst, San Diego, CA USA

[11] Univ Calif Davis, Dept Publ Hlth Sci, Div Biostat, Davis, CA 95616 USA

[12] Mayo Clin, Dept Neurol, Rochester, MN USA

[13] Univ Calif San Francisco, Ctr Imaging Neurodegenerat Dis, Dept Vet Affairs Med Ctr, San Francisco, CA 94143 USA

来源：

ALZHEIMERS & DEMENTIA | 2018年 / 14卷 / 08期

基金：

美国国家卫生研究院; 日本科学技术振兴机构; 加拿大健康研究院;

关键词：

Alzheimer's disease; ADNI; Mild cognitive impairment; Biomarker; Amyloid PET imaging; Harmonization; Japan; CLINICAL CHARACTERIZATION; ASSOCIATION; VARIABILITY;

D O I：

10.1016/j.jalz.2018.03.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: We conducted Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) and compared the basic characteristics and progression profiles with those of ADNI in North America. Methods: A total of 537 Japanese subjects with normal cognition, late amnestic mild cognitive impairment (LMCI), or mild Alzheimer's disease (AD) were enrolled using the same criteria as ADNI. Rates of changes in representative cognitive or functional measures were compared for amyloid positron emission tomography- or cerebrospinal fluid amyloid beta(1-42)-positive LMCI and mild AD between J-ADNI and ADNI. Results: Amyloid positivity rates were significantly higher in normal cognition of ADNI but at similar levels in LMCI and mild AD between J-ADNI and ADNI. Profiles of decline in cognitive or functional measures in amyloid-positive LMCI in J-ADNI (n = 75) and ADNI (n = 269) were remarkably similar, whereas those in mild AD were milder in J-ADNI (n = 73) compared with ADNI (n = 230). Discussion: These results support the feasibility of bridging of clinical trials in the prodromal stage of AD between Asia and western countries. (C) 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.

引用

页码：1077 / 1087

页数：11

共 26 条

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