Poly(2-oxazoline)-protein conjugates

被引：37

作者：

Sedlacek, Ondrej ^{[1
]}

de la Rosa, Victor R. ^{[1
]}

Hoogenboom, Richard ^{[1
]}

机构：

[1] Univ Ghent, Ctr Macromol Chem CMaC, Dept Organ & Macromol Chem, Supramol Chem Grp, Krijgslaan 281 S4, B-9000 Ghent, Belgium

来源：

EUROPEAN POLYMER JOURNAL | 2019年 / 120卷

关键词：

Bioconjugates; Polyoxazoline-peptide conjugates; Polyoxazoline-protein conjugates; IN-VITRO; FUNCTIONALIZED POLY(2-OXAZOLINE)S; BLOCK-COPOLYMERS; DRUG; POLY(2-ETHYL-2-OXAZOLINE); NANOPARTICLES; PEG; DIHYDROXYLATION; BIODISTRIBUTION; POXYLATION;

D O I：

10.1016/j.eurpolymj.2019.109246

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(2-oxazoline)s (in literature abbreviated as PAOx, POx, or POZ, herein referred to as PAOx) represent an emerging class of biocompatible polymers outperforming polyethylene glycol (PEG) in many aspects, including their high synthetic versatility and structural modularity. In this review, we provide a brief introduction to PAOx chemistry and biology to sketch their potential in biomaterials science. Further, we provide a detailed comprehensive overview of the literature on PAOx-protein conjugates with emphasis on their critical evaluation and comparison with analogous systems based on PEG. Based on this literature overview, PAOx seem to be an excellent alternative to PEG in the construction of therapeutic polymer-protein conjugates.

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页数：7

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