Treponema pallidum fibronectin-binding proteins

被引：65

作者：

Cameron, CE ^{[1
]}

Brown, EL ^{[1
]}

Kuroiwa, JMY ^{[1
]}

Schnapp, LM ^{[1
]}

Brouwer, NL ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Div Infect Dis, Seattle, WA 98195 USA

来源：

JOURNAL OF BACTERIOLOGY | 2004年 / 186卷 / 20期

关键词：

D O I：

10.1128/JB.186.20.7019-7022.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Putative adhesins were predicted by computer analysis of the Treponema pallidum genome. Two treponemal proteins, Tp0155 and Tp0483, demonstrated specific attachment to fibronectin, blocked bacterial adherence to fibronectin-coated slides, and supported attachment of fibronectin-producing mammalian cells. These results suggest Tp0155 and Tp0483 are fibronectin-binding proteins mediating T. pallidum-host interactions.

引用

页码：7019 / 7022

页数：4

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