Synthesis of -Ketoamide Curcumin Analogs for Anti-Diabetic and AGEs Inhibitory Activities

被引：15

作者：

Banuppriya, Govindharasu ^{[1
]}

Sribalan, Rajendran ^{[1
]}

Fathima, Sulthan Alavudeen Rizwan ^{[1
]}

Padmini, Vediappen ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai, Tamil Nadu, India

来源：

CHEMISTRY & BIODIVERSITY | 2018年 / 15卷 / 08期

关键词：

AGEs inhibitor; -amylase inhibition; -glucosidase inhibition; -ketoamide curcumin; ALPHA-AMYLASE; ANTIINFLAMMATORY AGENTS; DIABETIC COMPLICATIONS; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; IN-VITRO; GLYCATION; DESIGN; DERIVATIVES; MELLITUS;

D O I：

10.1002/cbdv.201800105

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two different series of novel -ketoamide curcumin analogs enriched in biological activities have been synthesized. The synthesized compounds were screened for their invitro anti-diabetic and AGEs inhibitory activities and exhibited potent to good anti-diabetic and AGEs inhibitory activities. The molecular docking study was also performed with the -amylase enzyme.

引用

页数：11

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