CORRELATION BETWEEN LYMPHATIC VESSEL DENSITY AND REGIONAL METASTASIS IN SQUAMOUS CELL CARCINOMA OF THE TONGUE

被引：18

作者：

Chung, Man Ki ^{[1
]}

Min, Jin-Young ^{[1
]}

So, Yoon Kyoung ^{[1
]}

Ko, Young-Hyeh ^{[2
]}

Jeong, Han-Sin ^{[1
]}

Son, Young-Ik ^{[1
]}

Baek, Chung-Hwan ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul, South Korea

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2010年 / 32卷 / 04期

关键词：

tongue; lymphatic vessel; squamous cell carcinoma; podoplanin; metastasis; NODE METASTASIS; INTRATUMORAL LYMPHANGIOGENESIS; TUMOR LYMPHANGIOGENESIS; ORAL-CAVITY; CANCER; INVASION; HEAD; PODOPLANIN; DEPTH;

D O I：

10.1002/hed.21202

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. The aim of this study was to investigate the correlation between lymphatic vessel density in squamous cell carcinoma of the tongue and regional metastasis. Methods. Intratumoral and peritumoral lymphatic densities (ILDs and PLDs, respectively) were determined by immunohistochemical staining of lymphatic endothelial cells with podoplanin in 62 patients surgically treated for tongue cancer. Clinicopathological variables were quantified, and their correlations with regional metastasis were assessed. Results. The rate of regional metastasis was significantly higher in patients with high ILD than that in those with low ILD (21/33, 63.6% vs 8/29, 27.5%; p = .006). Perineural invasion and lymphovascular invasion were also significantly correlated with regional metastasis. By multivariate analyses, ILD was the only variable identified to be significantly correlated with regional metastasis (p = .009). On the other hand, PLD showed no correlation with regional metastasis. Conclusions. ILD showed a strong correlation with regional metastasis in patients with squamous cell carcinoma of the tongue. (C) 2009 Wiley Periodicals, Inc Head Neck 32: 445451, 2010

引用

页码：445 / 451

页数：7

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