Atypical White Matter Connectivity in Dyslexic Readers of a Fairly Transparent Orthography

被引：13

作者：

Zaric, Gojko ^{[1
,2
]}

Timmers, Inge ^{[1
,3
]}

Gerretsen, Patty ^{[4
]}

Gonzalez, Gorka Fraga ^{[5
]}

Tijms, Jurgen ^{[6
]}

van der Molen, Maurits W. ^{[5
]}

Blomert, Leo ^{[1
,2
]}

Bonte, Milene ^{[1
,2
]}

机构：

[1] Maastricht Univ, Fac Psychol & Neurosci, Dept Cognit Neurosci, Maastricht, Netherlands

[2] Maastricht Brain Imaging Ctr M BIC, Maastricht, Netherlands

[3] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA

[4] Regionaal Inst Dyslexie, Maastricht, Netherlands

[5] Univ Amsterdam, Dept Dev Psychol, Amsterdam, Netherlands

[6] IWAL Inst Leerproblemen, Amsterdam, Netherlands

来源：

FRONTIERS IN PSYCHOLOGY | 2018年 / 9卷

关键词：

developmental dyslexia; structural connectivity; diffusion tensor imaging; reading network; anterior thalamic radiation; arcuate fasciculus; DIFFUSION TENSOR QUANTIFICATION; READING IMPAIRED CHILDREN; VERBAL WORKING-MEMORY; WORD FORM AREA; DEVELOPMENTAL DYSLEXIA; INDIVIDUAL-DIFFERENCES; ARCUATE FASCICULUS; BRAIN CONNECTIVITY; RIGHT-HEMISPHERE; PHONOLOGICAL AWARENESS;

D O I：

10.3389/fpsyg.2018.01147

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Atypical structural properties of the brain's white matter bundles have been associated with failing reading acquisition in developmental dyslexia. Because these white matter properties may show dynamic changes with age and orthographic depth, we examined fractional anisotropy (FA) along 16 white matter tracts in 8- to 11-year-old dyslexic (DR) and typically reading (TR) children learning to read in a fairly transparent orthography (Dutch). Our results showed higher FA values in the bilateral anterior thalamic radiations of DRs and FA values of the left thalamic radiation scaled with behavioral reading-related scores. Furthermore, DRs tended to have atypical FA values in the bilateral arcuate fasciculi. Children's age additionally predicted FA values along the tracts. Together, our findings suggest differential contributions of cortical and thalamo-cortical pathways to the developing reading network in dyslexic and typical readers, possibly indicating prolonged letter-by-letter reading or increased attentional and/or working memory demands in dyslexic children during reading.

引用

页数：15

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