A Review of the Role of Micronutrients and Bioactive Compounds on Immune System Supporting to Fight against the COVID-19 Disease

被引:29
作者
Camara, Montana [1 ]
Sanchez-Mata, Maria Cortes [1 ]
Fernandez-Ruiz, Virginia [1 ]
Camara, Rosa Maria [1 ]
Cebadera, Elena [1 ]
Dominguez, Laura [1 ]
机构
[1] Complutense Univ Madrid UCM, Nutr & Food Sci Dept, Pharm Fac, Plaza Ramon y Cajal S-N, E-28040 Madrid, Spain
关键词
health claims; immune system; micronutrients; vitamin D; food supplements; COVID-19; VITAMIN-C; MANAGEMENT; NUTRIENTS; NUTRITION; THERAPY; FOODS;
D O I
10.3390/foods10051088
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Micronutrients are critical for an adequate function of the immune system and play a vital role in promoting health and nutritional well-being. The present work is aimed at reviewing (1) the role of micronutrients in helping the immune system to fight against the COVID-19 disease through the diet with food or food supplements and (2) the potential use of food health claims regarding immune function according to the European Food Safety Authority (EFSA) requirements. Till date, there are some health claims authorized by the European Commission that refer to the role of certain essential nutrients (vitamins B-6, B-9, B-12, A, D, C, and Cu, Fe, Se) to contribute to the proper functioning of the immune system. Vitamins D, C, Zn, and Se, have been thoroughly studied as a strategy to improve the immune system to fight against COVID-19 disease. From all the micronutrients, Vitamin D is the one with more scientific evidence suggesting positive effects against COVID-19 disease as it is linked to a reduction of infection rates, as well as an improved outcomes in patients. To validate scientific evidence, different clinical trials are ongoing currently, with promising preliminary results although inconclusive yet.
引用
收藏
页数:15
相关论文
共 103 条
[1]  
Abdulah DM, 2020, J NUTR HEALTH AGING, DOI [10.1007/s12603-020-1434-0, 10.1007/s12603-020-1512-3]
[2]   Caffeic acid derivatives (CAFDs) as inhibitors of SARS-CoV-2: CAFDs-based functional foods as a potential alternative approach to combat COVID-19 [J].
Adem, Sevki ;
Eyupoglu, Volkan ;
Sarfraz, Iqra ;
Rasul, Azhar ;
Zahoor, Ameer Fawad ;
Ali, Muhammad ;
Abdalla, Mohnad ;
Ibrahim, Ibrahim M. ;
Elfiky, Abdo A. .
PHYTOMEDICINE, 2021, 85
[3]   Antiviral Functional Foods and Exercise Lifestyle Prevention of Coronavirus [J].
Alkhatib, Ahmad .
NUTRIENTS, 2020, 12 (09) :1-17
[4]   How Nutrition can help to fight against COVID-19 Pandemic [J].
Aman, Faseeha ;
Masood, Sadia .
PAKISTAN JOURNAL OF MEDICAL SCIENCES, 2020, 36 (04) :S121-S123
[5]   Is innate immunity our best weapon for flattening the curve? [J].
Angka, Leonard ;
Market, Marisa ;
Ardolino, Michele ;
Auer, Rebecca C. .
JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (08) :3954-3956
[6]  
[Anonymous], EFFECT VITAMIN D SUP
[7]  
[Anonymous], 2006, Official Journal of the European Union
[8]   Coronavirus disease (COVID-19) and immunity booster green foods: A mini review [J].
Arshad, Muhammad Sajid ;
Khan, Urooj ;
Sadiq, Anam ;
Khalid, Waseem ;
Hussain, Muhammad ;
Yasmeen, Ammara ;
Asghar, Zubia ;
Rehana, Hafiza .
FOOD SCIENCE & NUTRITION, 2020, 8 (08) :3971-3976
[9]   The Role of Vitamin C, Vitamin D, and Selenium in Immune System against COVID-19 [J].
Bae, Minkyung ;
Kim, Hyeyoung .
MOLECULES, 2020, 25 (22)
[10]   Dual and mutual interaction between microbiota and viral infections: a possible treat for COVID-19 [J].
Baghbani, Taha ;
Nikzad, Hossein ;
Azadbakht, Javid ;
Izadpanah, Fatemeh ;
Kashani, Hamed Haddad .
MICROBIAL CELL FACTORIES, 2020, 19 (01)