Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s for biomedical applications

被引：17

作者：

Nishimura, Tomoki ^{[1
]}

Sumi, Naoki ^{[1
]}

Mukai, Sada-atsu ^{[1
]}

Sasaki, Yoshihiro ^{[1
]}

Akiyoshi, Kazunari ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Polymer Chem, Nishikyo Ku, Kyoto 6158510, Japan

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2019年 / 7卷 / 41期

关键词：

BLOCK-COPOLYMER MICELLES; CYLINDRICAL MICELLES; AQUEOUS-SOLUTIONS; POLY(2-OXAZOLINE)S; NANOPARTICLES; GELATORS; GELATION; WATER;

D O I：

10.1039/c9tb00918c

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

An approach for the preparation of self-healing and injectable hydrogels based on the crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s is reported. Hydrogelation does not require any organic solvents, as the polymers dissolve in water below their lower critical solution temperatures. The transplanted hydrogels cause no significant foreign-body response. Considering the simplicity of the method and the biocompatibility of the resulting injectable hydrogels, crystallization-driven hydrogelation of poly(oxazoline)-based polymers may potentially be used in a wide range of biomedical applications.

引用

页码：6362 / 6369

页数：8

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