Vasoinhibins and the Pituitary Gland

被引：0

作者：

Mendez, Isabel ^{[1
,2
]}

Vega, Claudia ^{[1
]}

Zamorano, Miriam ^{[1
]}

Moreno-Carranza, Bibiana ^{[1
]}

Martinez de la Escalera, Gonzalo ^{[1
]}

Clapp, Carmen ^{[1
]}

机构：

[1] UNAM, Inst Neurobiol, Queretaro 76230, Qro, Mexico

[2] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico

来源：

PITUITARY TODAY II: NEW MOLECULAR, PHYSIOLOGICAL AND CLINICAL ASPECTS | 2010年 / 38卷

关键词：

N-TERMINAL FRAGMENTS; CLEAVED PROLACTIN; CATHEPSIN-D; RAT PITUITARY; HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM; VASCULAR FUNCTION; POTENTIAL ROLE; ANGIOGENESIS; VASOPRESSIN; EXPRESSION;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vasoinhibins are a family of peptides that inhibit blood vessel growth, dilation, permeability, and survival. They are generated by the proteolytic cleavage of prolactin by cathepsin D, matrix metalloproteases, and bone morphogenic protein-1. Lactotropes within the anterior pituitary gland produce and release vasoinhibins. Hypothalamic neurons within the supraoptic and paraventricular nuclei also synthesize prolactin and process it to vasoinhibins that are released locally or at the neurohypophyseal endings. While both the anterior and posterior pituitaries may function as sources of circulating vasoinhibins, these peptides could act as local regulators of pituitary gland functions including neovascularization and neurohypophyseal hormone release. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：184 / 189

页数：6