Vasoinhibins and the Pituitary Gland

被引：0

作者：

Mendez, Isabel ^{[1
,2
]}

Vega, Claudia ^{[1
]}

Zamorano, Miriam ^{[1
]}

Moreno-Carranza, Bibiana ^{[1
]}

Martinez de la Escalera, Gonzalo ^{[1
]}

Clapp, Carmen ^{[1
]}

机构：

[1] UNAM, Inst Neurobiol, Queretaro 76230, Qro, Mexico

[2] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico

来源：

PITUITARY TODAY II: NEW MOLECULAR, PHYSIOLOGICAL AND CLINICAL ASPECTS | 2010年 / 38卷

关键词：

N-TERMINAL FRAGMENTS; CLEAVED PROLACTIN; CATHEPSIN-D; RAT PITUITARY; HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM; VASCULAR FUNCTION; POTENTIAL ROLE; ANGIOGENESIS; VASOPRESSIN; EXPRESSION;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vasoinhibins are a family of peptides that inhibit blood vessel growth, dilation, permeability, and survival. They are generated by the proteolytic cleavage of prolactin by cathepsin D, matrix metalloproteases, and bone morphogenic protein-1. Lactotropes within the anterior pituitary gland produce and release vasoinhibins. Hypothalamic neurons within the supraoptic and paraventricular nuclei also synthesize prolactin and process it to vasoinhibins that are released locally or at the neurohypophyseal endings. While both the anterior and posterior pituitaries may function as sources of circulating vasoinhibins, these peptides could act as local regulators of pituitary gland functions including neovascularization and neurohypophyseal hormone release. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：184 / 189

页数：6

共 31 条

[1] Intrahypothalamic angiogenesis induced by osmotic stimuli correlates with local hypoxia: A potential role of confined vasoconstriction induced by dendritic secretion of vasopressin
Alonso, Gerard
Gallibert, Evelyne
Lafont, Chrystel
Guillon, Gilles
[J]. ENDOCRINOLOGY, 2008, 149 (09) : 4279 - 4288
[2] GENE-EXPRESSION - DIALOG WITH THE CELL-CYCLE
ANDREWS, BJ
[J]. NATURE, 1992, 355 (6359) : 393 - 394
[3] Prolactins are natural inhibitors of angiogenesis in the retina
Aranda, J
Rivera, JC
Jeziorski, MC
Riesgo-Escovar, J
Nava, G
López-Barrera, F
Quiróz-Mercado, H
Berger, P
de la Escalera, GM
Clapp, C
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46 (08) : 2947 - 2953
[4] MASS-SPECTROMETRIC ANALYSIS OF THE FRAGMENTS PRODUCED BY CLEAVAGE AND REDUCTION OF RAT PROLACTIN - EVIDENCE THAT THE CLEAVING ENZYME IS CATHEPSIN-D
BALDOCCHI, RA
TAN, L
KING, DS
NICOLL, CS
[J]. ENDOCRINOLOGY, 1993, 133 (02) : 935 - 938
[5] THE 16-KILODALTON N-TERMINAL FRAGMENT OF HUMAN PROLACTIN IS A POTENT INHIBITOR OF ANGIOGENESIS
CLAPP, C
MARTIAL, JA
GUZMAN, RC
RENTIERDELRUE, F
WEINER, RI
[J]. ENDOCRINOLOGY, 1993, 133 (03) : 1292 - 1299
[6] BIOLOGICAL AND IMMUNOLOGICAL CHARACTERIZATION OF CLEAVED AND 16K FORMS OF RAT PROLACTIN
CLAPP, C
SEARS, PS
RUSSELL, DH
RICHARDS, J
LEVAYYOUNG, BK
NICOLL, CS
[J]. ENDOCRINOLOGY, 1988, 122 (06) : 2892 - 2898
[7] THE PROLACTIN GENE IS EXPRESSED IN THE HYPOTHALAMIC-NEUROHYPOPHYSEAL SYSTEM AND THE PROTEIN IS PROCESSED INTO A 14-KDA FRAGMENT WITH ACTIVITY LIKE 16-KDA PROLACTIN
CLAPP, C
TORNER, L
GUTIERREZOSPINA, G
ALCANTARA, E
LOPEZGOMEZ, FJ
NAGANO, M
KELLY, PA
MEJIA, S
MORALES, MA
DELAESCALERA, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (22) : 10384 - 10388
[8] Vasoinhibins:: novel inhibitors of ocular angiogenesis
Clapp, Carmen
Thebault, Stephanie
Arnold, Edith
Garcia, Celina
Rivera, Jose Carlos
de la Escalera, Gonzalo Martinez
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 295 (04): : E772 - E778
[9] Role of prolactin and vasoinhibins in the regulation of vascular function in mammary gland
Clapp, Carmen
Thebault, Stephanie
Martinez de la Escalera, Gonzalo
[J]. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2008, 13 (01) : 55 - 67
[10] Vasoinhibins:: endogenous regulators of angiogenesis and vascular function
Clapp, Carmen
Aranda, Jorge
Gonzalez, Carmen
Jeziorski, Michael C.
de la Escalera, Gonzalo Martinez
[J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2006, 17 (08) : 301 - 307

← 1 2 3 4 →