From molecular networks to qualitative cell behavior

被引：25

作者：

Gagneur, J ^{[1
]}

Casari, G ^{[1
]}

机构：

[1] Cellzome AG, D-69117 Heidelberg, Germany

来源：

FEBS LETTERS | 2005年 / 579卷 / 08期

关键词：

qualitative model; systems biology; constraint-based approach; metabolic network; gene regulatory network;

D O I：

10.1016/j.febslet.2005.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adaptation and behavior are characteristics of life which are fundamentally dynamic. If we want to model the living cell we have to describe it as a dynamic system. Typical dynamic models are based on quantitative differential equations requiring very detailed kinetic knowledge. Alternative modeling techniques for less fine-grained information are better suited to available functional genomics data. As such, constraint-based techniques and qualitative modeling have proven themselves to be valid approaches in cell biology. These approaches offer formal support to check the consistency of molecular networks against phenotypic observations in the light of dynamic systems. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1867 / 1871

页数：5

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