A role for adult neurogenesis in spatial long-term memory

被引：690
作者：
Snyder, JS
Hong, NS
McDonald, RJ
Wojtowicz, JM
机构：
[1] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada
[2] Univ Lethbridge, Canadian Ctr Behav Neurosci, Dept Psychol & Neurosci, Lethbridge, AB T1K 3M4, Canada
来源：
NEUROSCIENCE | 2005年 / 130卷 / 04期
基金：
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词：
plasticity; hippocampus; radiation; consolidation; dentate gyrus; learning;
D O I：
10.1016/j.neuroscience.2004.10.009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Adult hippocampal neurogenesis has been linked to learning but details of the relationship between neuronal production and memory formation remain unknown. Using low dose irradiation to inhibit adult hippocampal neurogenesis we show that new neurons aged 4-28 days old at the time of training are required for long-term memory in a spatial version of the water maze. This effect of irradiation was specific since long-term memory for a visibly cued platform remained intact. Furthermore, irradiation just before or after water maze training had no effect on learning or long-term memory. Relationships between learning and new neuron survival, as well as proliferation, were investigated but found non-significant. These results suggest a new role for adult neurogenesis in the formation and/or consolidation of longterm, hippocampus-dependent, spatial memories. (C) 2004 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：843 / 852
页数：10
相关论文
共 54 条
[1]   AUTORADIOGRAPHIC AND HISTOLOGICAL EVIDENCE OF POSTNATAL HIPPOCAMPAL NEUROGENESIS IN RATS [J].
ALTMAN, J ;
DAS, GD .
JOURNAL OF COMPARATIVE NEUROLOGY, 1965, 124 (03) :319-&
[2]   Spatial learning affects immature granule cell survival in adult rat dentate gyrus [J].
Ambrogini, P ;
Cuppini, R ;
Cuppini, C ;
Ciaroni, S ;
Cecchini, T ;
Ferri, P ;
Sartini, S ;
Del Grande, P .
NEUROSCIENCE LETTERS, 2000, 286 (01) :21-24
[3]   Learning may reduce neurogenesis in adult rat dentate gyrus [J].
Ambrogini, P ;
Orsini, L ;
Mancini, C ;
Ferri, P ;
Ciaroni, S ;
Cuppini, R .
NEUROSCIENCE LETTERS, 2004, 359 (1-2) :13-16
[4]   Transient expression of doublecortin during adult neurogenesis [J].
Brown, JP ;
Couillard-Després, S ;
Cooper-Kuhn, CM ;
Winkler, J ;
Aigner, L ;
Kuhn, HG .
JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 467 (01) :1-10
[5]   Retrograde amnesia for spatial memory induced by NMDA receptor-mediated long-term potentiation [J].
Brun, VH ;
Ytterbo, K ;
Morris, RGM ;
Moser, MB ;
Moser, EI .
JOURNAL OF NEUROSCIENCE, 2001, 21 (01) :356-362
[6]   Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus [J].
Cameron, HA ;
McKay, RDG .
JOURNAL OF COMPARATIVE NEUROLOGY, 2001, 435 (04) :406-417
[7]   Short-term and long-term survival of new neurons in the rat dentate gyrus [J].
Dayer, AG ;
Ford, AA ;
Cleaver, KM ;
Yassaee, M ;
Cameron, HA .
JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 460 (04) :563-572
[8]   Cellular and systems reconsolidation in the hippocampus [J].
Debiec, J ;
LeDoux, JE ;
Nader, K .
NEURON, 2002, 36 (03) :527-538
[9]   Differential effects of learning on neurogenesis:: learning increases or decreases the number of newly born cells depending on their birth date [J].
Döbrössy, MD ;
Drapeau, E ;
Aurousseau, C ;
Le Moal, M ;
Piazza, PV ;
Abrous, DN .
MOLECULAR PSYCHIATRY, 2003, 8 (12) :974-982
[10]   The hippocampus, memory, and place cells: Is it spatial memory or a memory space? [J].
Eichenbaum, H ;
Dudchenko, P ;
Wood, E ;
Shapiro, M ;
Tanila, H .
NEURON, 1999, 23 (02) :209-226
123456