Sex Differences in Autism Spectrum Disorder: Focus on High Functioning Children and Adolescents

被引:54
作者
de Giambattista, Concetta [1 ]
Ventura, Patrizia [1 ]
Trerotoli, Paolo [2 ]
Margari, Francesco [3 ]
Margari, Lucia [1 ]
机构
[1] Univ Bari Aldo Moro, Child Neuropsychiat Unit, Bari, Italy
[2] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Bari, Italy
[3] Univ Bari Aldo Moro, Psychiat Emergencies Adolescence Unit, Bari, Italy
关键词
autism spectrum disorder; high functioning; female; gender; sex; GENDER-DIFFERENCES; ASPERGER-SYNDROME; CHILDHOOD AUTISM; ANOREXIA-NERVOSA; FEMALES; ADULTS; GIRLS; BRAIN; MALES; BOYS;
D O I
10.3389/fpsyt.2021.539835
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Autism Spectrum Disorder (ASD) has historically been studied, known, and diagnosed in males. Females tend to remain unidentified, especially those with average intelligence abilities. This sex/gender difference might be partially explained by biological risk factors, but it is probably also bound to methodological issues. The present study aims to examine phenotypic characteristics (cognitive, emotive, socio-communicative, and academic) of a group of 54 females with ASD matched to a group of 55 males with ASD (3-18 years), all without cognitive impairment. Results suggest that there are subtle, yet potentially meaningful, quantitative, and qualitative phenotypic differences between females and males that common screening tests are not always sensitive enough to recognize. Further studies to improve practice and course for the assessment of females, reducing sex/gender-based inequities in ASD care, are required.
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页数:13
相关论文
共 103 条
[1]  
Achenbach T.M., 1999, USE PSYCHOL TESTING, P429
[2]   Sex differences in autism: a resting-state fMRI investigation of functional brain connectivity in males and females [J].
Alaerts, Kaat ;
Swinnen, Stephan P. ;
Wenderoth, Nicole .
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2016, 11 (06) :1002-1016
[3]  
American Psychiatric Association, 2022, Diagnostic and statistical manual of mental disorders, DOI DOI 10.1176/APPI.BOOKS.9780890425596
[4]   Pre-school children with suspected autism spectrum disorders: Do girls and boys have the same profiles? [J].
Andersson, Gunilla Westman ;
Gillberg, Christopher ;
Miniscalco, Carmela .
RESEARCH IN DEVELOPMENTAL DISABILITIES, 2013, 34 (01) :413-422
[5]   Autism Spectrum Disorders and ADHD: Overlapping Phenomenology, Diagnostic Issues, and Treatment Considerations [J].
Antshel, Kevin M. ;
Russo, Natalie .
CURRENT PSYCHIATRY REPORTS, 2019, 21 (05)
[6]   The ''autistic psychopathy'' in childhood [J].
Asperger, H .
ARCHIV FUR PSYCHIATRIE UND NERVENKRANKHEITEN, 1944, 117 (01) :76-136
[7]  
Attwood T., 2006, The complete guide to Asperger's syndrome
[8]   Prenatal and postnatal hormone effects on the human brain and cognition [J].
Auyeung, Bonnie ;
Lombardo, Michael V. ;
Baron-Cohen, Simon .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2013, 465 (05) :557-571
[9]   The Children's Empathy Quotient and Systemizing Quotient: Sex Differences in Typical Development and in Autism Spectrum Conditions [J].
Auyeung, Bonnie ;
Wheelwright, Sally ;
Allison, Carrie ;
Atkinson, Matthew ;
Samarawickrema, Nelum ;
Baron-Cohen, Simon .
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2009, 39 (11) :1509-1521
[10]   Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014 [J].
Baio, Jon ;
Wiggins, Lisa ;
Christensen, Deborah L. ;
Maenner, Matthew J. ;
Daniels, Julie ;
Warren, Zachary ;
Kurzius-Spencer, Margaret ;
Zahorodny, Walter ;
Rosenberg, Cordelia Robinson ;
White, Tiffany ;
Durkin, Maureen S. ;
Imm, Pamela ;
Nikolaou, Loizos ;
Yeargin-Allsopp, Marshalyn ;
Lee, Li-Ching ;
Harrington, Rebecca ;
Lopez, Maya ;
Fitzgerald, Robert T. ;
Hewitt, Amy ;
Pettygrove, Sydney ;
Constantino, John N. ;
Vehorn, Alison ;
Shenouda, Josephine ;
Hall-Lande, Jennifer ;
Braun, Kim Van Naarden ;
Dowling, Nicole F. .
MMWR SURVEILLANCE SUMMARIES, 2018, 67 (06) :1-23