Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

被引：116

作者：

Dickinson, Anne M. ^{[1
]}

Norden, Jean ^{[1
]}

Li, Shuang ^{[2
]}

Hromadnikova, Ilona ^{[2
]}

Schmid, Christoph ^{[3
]}

Schmetzer, Helga ^{[4
]}

Jochem-Kolb, Hans ^{[5
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Haematol Sci, Newcastle Upon Tyne, Tyne & Wear, England

[2] Charles Univ Prague, Dept Mol Biol & Cell Pathol, Fac Med 3, Prague, Czech Republic

[3] Univ Hosp Augsburg, Dept Hematopoiet Cell Transplantat, Munich, Germany

[4] Hosp Univ Munich, Internal Med 3, Dept Hematopoiet Cell Transplantat, Munich, Germany

[5] Klinikum Munchen Schwabing, Dept Hematol Oncol Immunol Infect Dis, Munich, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷

关键词：

graft-versus-leukemia effect; animal models; donor lymphocyte infusion; allogenic natural killer cells; leukaemia associated antigens (LAA); LAA specific T cells; leukaemia derived dendritic cells; invariant natural killer T cells (i)NKT; leukaemia specific antigens; NATURAL-KILLER-CELLS; DONOR LYMPHOCYTE INFUSION; ALLOGENEIC BONE-MARROW; ACUTE MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; MINOR-HISTOCOMPATIBILITY-ANTIGENS; PERIPHERAL-BLOOD LYMPHOCYTES; ACUTE LYMPHOBLASTIC-LEUKEMIA; REGULATORY T-CELLS; CORD BLOOD;

D O I：

10.3389/fimmu.2017.00496

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.

引用

页数：16

共 181 条

[51] Minor histocompatibility antigens in human stem cell transplantation [J].

Falkenburg, JHF ;

van de Corput, L ;

Marijt, EWA ;

Willemze, R .

EXPERIMENTAL HEMATOLOGY, 2003, 31 (09) :743-751

[52]

Field E O, 1966, Clin Exp Immunol, V1, P195

[53] Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1 [J].

Gao, LQ ;

Bellantuono, I ;

Elsässer, A ;

Marley, SB ;

Gordon, MY ;

Goldman, JM ;

Stauss, HJ .

BLOOD, 2000, 95 (07) :2198-2203

[54] DLI after haploidentical BMT with post-transplant CY [J].

Ghiso, A. ;

Raiola, A. M. ;

Gualandi, F. ;

Dominietto, A. ;

Varaldo, R. ;

Van Lint, M. T. ;

Bregante, S. ;

Di Grazia, C. ;

Lamparelli, T. ;

Galaverna, F. ;

Stasia, A. ;

Luchetti, S. ;

Geroldi, S. ;

Grasso, R. ;

Colombo, N. ;

Bacigalupo, A. .

BONE MARROW TRANSPLANTATION, 2015, 50 (01) :56-61

[55] CD8-DEPLETED DONOR LYMPHOCYTE INFUSION AS TREATMENT FOR RELAPSED CHRONIC MYELOGENOUS LEUKEMIA AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION [J].

GIRALT, S ;

HESTER, J ;

HUH, Y ;

HIRSCHGINSBERG, C ;

RONDON, G ;

SEONG, D ;

LEE, M ;

GAJEWSKI, J ;

VANBESIEN, K ;

KHOURI, I ;

MEHRA, R ;

PRZEPIORKA, D ;

KORBLING, M ;

TALPAZ, M ;

KANTARJIAN, H ;

FISCHER, H ;

DEISSEROTH, A ;

CHAMPLIN, R .

BLOOD, 1995, 86 (11) :4337-4343

[56] LEUKEMIA RELAPSE AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION - A REVIEW [J].

GIRALT, SA ;

CHAMPLIN, RE .

BLOOD, 1994, 84 (11) :3603-3612

[57] CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets [J].

Gleason, Michelle K. ;

Ross, Julie A. ;

Warlick, Erica D. ;

Lund, Troy C. ;

Verneris, Michael R. ;

Wiernik, Andres ;

Spellman, Stephen ;

Haagenson, Michael D. ;

Lenvik, Alexander J. ;

Litzow, Mark R. ;

Epling-Burnette, Pearlie K. ;

Blazar, Bruce R. ;

Weiner, Louis M. ;

Weisdorf, Daniel J. ;

Vallera, Daniel A. ;

Miller, Jeffrey S. .

BLOOD, 2014, 123 (19) :3016-3026

[58] Bispecific and Trispecific Killer Cell Engagers Directly Activate Human NK Cells through CD16 Signaling and Induce Cytotoxicity and Cytokine Production [J].

Gleason, Michelle K. ;

Verneris, Michael R. ;

Todhunter, Deborah A. ;

Zhang, Bin ;

McCullar, Valarie ;

Zhou, Sophia X. ;

Panoskaltsis-Mortari, Angela ;

Weiner, Louis M. ;

Vallera, Daniel A. ;

Miller, Jeffrey S. .

MOLECULAR CANCER THERAPEUTICS, 2012, 11 (12) :2674-2684

[59]

GOULMY E, 1976, LANCET, V2, P1206

[60] Mutated regions of nucleophosmin 1 elicit both CD4+ and CD8+ T-cell responses in patients with acute myeloid leukemia [J].

Greiner, Jochen ;

Ono, Yoko ;

Hofmann, Susanne ;

Schmitt, Anita ;

Mehring, Elmar ;

Goetz, Marlies ;

Guillaume, Philippe ;

Doehner, Konstanze ;

Mytilineos, Joannis ;

Doehner, Hartmut ;

Schmitt, Michael .

BLOOD, 2012, 120 (06) :1282-1289

← 1 2 3 4 5 6 7 8 9 10 →