Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

被引：116

作者：

Dickinson, Anne M. ^{[1
]}

Norden, Jean ^{[1
]}

Li, Shuang ^{[2
]}

Hromadnikova, Ilona ^{[2
]}

Schmid, Christoph ^{[3
]}

Schmetzer, Helga ^{[4
]}

Jochem-Kolb, Hans ^{[5
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Haematol Sci, Newcastle Upon Tyne, Tyne & Wear, England

[2] Charles Univ Prague, Dept Mol Biol & Cell Pathol, Fac Med 3, Prague, Czech Republic

[3] Univ Hosp Augsburg, Dept Hematopoiet Cell Transplantat, Munich, Germany

[4] Hosp Univ Munich, Internal Med 3, Dept Hematopoiet Cell Transplantat, Munich, Germany

[5] Klinikum Munchen Schwabing, Dept Hematol Oncol Immunol Infect Dis, Munich, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷

关键词：

graft-versus-leukemia effect; animal models; donor lymphocyte infusion; allogenic natural killer cells; leukaemia associated antigens (LAA); LAA specific T cells; leukaemia derived dendritic cells; invariant natural killer T cells (i)NKT; leukaemia specific antigens; NATURAL-KILLER-CELLS; DONOR LYMPHOCYTE INFUSION; ALLOGENEIC BONE-MARROW; ACUTE MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; MINOR-HISTOCOMPATIBILITY-ANTIGENS; PERIPHERAL-BLOOD LYMPHOCYTES; ACUTE LYMPHOBLASTIC-LEUKEMIA; REGULATORY T-CELLS; CORD BLOOD;

D O I：

10.3389/fimmu.2017.00496

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.

引用

页数：16

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