Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

被引：116
作者：
Dickinson, Anne M. [1 ]
Norden, Jean [1 ]
Li, Shuang [2 ]
Hromadnikova, Ilona [2 ]
Schmid, Christoph [3 ]
Schmetzer, Helga [4 ]
Jochem-Kolb, Hans [5 ]
机构：
[1] Newcastle Univ, Inst Cellular Med, Haematol Sci, Newcastle Upon Tyne, Tyne & Wear, England
[2] Charles Univ Prague, Dept Mol Biol & Cell Pathol, Fac Med 3, Prague, Czech Republic
[3] Univ Hosp Augsburg, Dept Hematopoiet Cell Transplantat, Munich, Germany
[4] Hosp Univ Munich, Internal Med 3, Dept Hematopoiet Cell Transplantat, Munich, Germany
[5] Klinikum Munchen Schwabing, Dept Hematol Oncol Immunol Infect Dis, Munich, Germany
来源：
FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷
关键词：
graft-versus-leukemia effect; animal models; donor lymphocyte infusion; allogenic natural killer cells; leukaemia associated antigens (LAA); LAA specific T cells; leukaemia derived dendritic cells; invariant natural killer T cells (i)NKT; leukaemia specific antigens; NATURAL-KILLER-CELLS; DONOR LYMPHOCYTE INFUSION; ALLOGENEIC BONE-MARROW; ACUTE MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; MINOR-HISTOCOMPATIBILITY-ANTIGENS; PERIPHERAL-BLOOD LYMPHOCYTES; ACUTE LYMPHOBLASTIC-LEUKEMIA; REGULATORY T-CELLS; CORD BLOOD;
D O I：
10.3389/fimmu.2017.00496
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.
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页数：16
相关论文
共 181 条
[1]   Differential activation of cord blood and peripheral blood natural killer cells by cytokines [J].
Alnabhan, Rehab ;
Madrigal, Alejandro ;
Saudemont, Aurore .
CYTOTHERAPY, 2015, 17 (01) :73-85
[2]   T-cell-depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patients with multiple myeloma: induction of graft-versus-myeloma effect [J].
Alyea, E ;
Weller, E ;
Schlossman, R ;
Canning, C ;
Webb, I ;
Doss, D ;
Mauch, P ;
Marcus, K ;
Fisher, D ;
Freeman, A ;
Parikh, B ;
Gribben, J ;
Soiffer, R ;
Ritz, J ;
Anderson, K .
BLOOD, 2001, 98 (04) :934-939
[3]  
Anderson BE, 2008, BIOL BLOOD MARROW TR, V14, P19
[4]  
Apperley Jane F, 2006, Hematology Am Soc Hematol Educ Program, P226
[5]   Adoptive immunotherapy with donor lymphocyte infusions and interleukin-2 after high-dose therapy and autologous stem cell rescue for multiple myeloma [J].
Ballester, OF ;
Fang, T ;
Raptis, A ;
Ballester, G ;
Wilcox, P ;
Hiemenz, J ;
Tan, B .
BONE MARROW TRANSPLANTATION, 2004, 34 (05) :419-423
[6]   TREATMENT OF MURINE LEUKAEMIA WITH X-RAYS AND HOMOLOGOUS BONE MARROW - PRELIMINARY COMMUNICATION [J].
BARNES, DWH ;
CORP, MJ ;
LOUTIT, JF ;
NEAL, FE .
BRITISH MEDICAL JOURNAL, 1956, 2 (SEP15) :626-627
[7]   What Is the Role for Donor Natural Killer Cells after Nonmyeloablative Conditioning? [J].
Baron, Frederic ;
Petersdorf, Effie W. ;
Gooley, Ted ;
Sandmaier, Brenda M. ;
Malkki, Mari ;
Chouncey, Thomas R. ;
Maloney, David G. ;
Storb, Rainer .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2009, 15 (05) :580-588
[8]   Stem cell transplantation with reduced-intensity conditioning regimens: a review of ten years experience with new transplant concepts and new therapeutic agents [J].
Barrett, A. J. ;
Savani, B. N. .
LEUKEMIA, 2006, 20 (10) :1661-1672
[9]   Understanding and harnessing the graft-versus-leukaemia effect [J].
Barrett, A. John .
BRITISH JOURNAL OF HAEMATOLOGY, 2008, 142 (06) :877-888
[10]   Allogeneic stem cell transplantation for myelodysplastic syndrome [J].
Barrett, A. John ;
Savani, Bipin N. .
SEMINARS IN HEMATOLOGY, 2008, 45 (01) :49-59
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