Neuroprotective effect of YM-39558, orotic acid ethylester, in gerbil forebrain ischemia

被引：4

作者：

Akiho, H ^{[1
]}

Iwai, A ^{[1
]}

Katoh-Sudoh, M ^{[1
]}

Tsukamoto, S ^{[1
]}

Koshiya, K ^{[1
]}

Yamaguchi, T ^{[1
]}

机构：

[1] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Pharmacol Labs, Neurosci Res, Tsukuba, Ibaraki 3058585, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1998年 / 76卷 / 04期

关键词：

orotic acid; YM-39558; cerebral ischemia;

D O I：

10.1254/jjp.76.441

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We studied the effects of erotic acid and YM-39558 (2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid ethyl ester), erotic acid ethylester, on delayed neuronal death of hippocampal CAl neurons induced by transient forebrain ischemia. Our data indicated that YM-39558 had high permeability across the blood brain barrier and was hydrolyzed to erotic acid, the active substance, in the brain. The neuronal damage was reduced significantly in animals intraperitoneally treated with YM-39558 (100 mg/kg x 3) after ischemia, but not with erotic acid in the same way. The results also suggested that the maintenance of a few ten micromolar erotic acid in cerebrospinal fluid were needed for its neuroprotective effects.

引用

页码：441 / 444

页数：4

共 16 条

[1] Post-ischaemic treatment with orotic acid prevents neuronal injury in gerbil brain ischaemia [J].