IL-1α responds to necrotic cell death

被引：21

作者：

Elkon, Keith B.

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

[2] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

来源：

NATURE MEDICINE | 2007年 / 13卷 / 07期

关键词：

D O I：

10.1038/nm0707-778

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Necrosis induces inflammation, but how necrotic cells signal to immune cells was poorly understood. New work by Chen et al. shows that IL-1 alpha acts as a mediator, translating a signal from the necrotic cells to induce the recruitment of immune cells to the site of injury (pages 851-856).

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页码：778 / 780

页数：4

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