Peptide correction of age-related hormonal dysfunction of the pancreas in monkeys

被引:0
作者
Goncharova, ND [1 ]
Vengerin, AA
Khavinson, VK
Lapin, BA
机构
[1] Russian Acad Med Sci, Inst Med Primato, Soci, Russia
[2] Russian Acad Med Sci, St Petersburg Inst Bioregulat & Gerontol, NW Div, St Petersburg, Russia
关键词
aging; pancreas; Epithalon; monkeys;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We studied the effect of Epithalon on the function of pancreatic islets and regulation of blood glucose level in female rhesus monkeys of various ages. Epithalon corrected the age-related decrease in glucose tolerance and restored the dynamics of insulin level in response to glucose load.
引用
收藏
页码:80 / 83
页数:4
相关论文
共 9 条
[1]  
Ametov A. S., 2002, Problemy Endokrinologii, V48, P31
[2]   Glucose regulation and oxidative stress in healthy centenarians [J].
Barbieri, M ;
Rizzo, MR ;
Manzella, D ;
Grella, R ;
Ragno, E ;
Carbonella, M ;
Abbatecola, AM ;
Paolisso, G .
EXPERIMENTAL GERONTOLOGY, 2003, 38 (1-2) :137-143
[3]   Nonhuman Primate Models of Menopause Workshop [J].
Bellino, FL ;
Wise, PM .
BIOLOGY OF REPRODUCTION, 2003, 68 (01) :10-18
[4]  
GONCHAROVA ND, 2001, B EKSP BIOL MED, V131, P466
[5]  
GONCHAROVA ND, 2004, B EKSP BIOL MED, V137, P317
[6]   HYPERINSULINEMIA IS ASSOCIATED WITH ALTERED INSULIN-RECEPTOR MESSENGER-RNA SPLICING IN MUSCLE OF THE SPONTANEOUSLY OBESE-DIABETIC RHESUS-MONKEY [J].
HUANG, Z ;
BODKIN, NL ;
ORTMEYER, HK ;
HANSEN, BC ;
SHULDINER, AR .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (03) :1289-1296
[7]   Oxidative stress in diabetic rats induced by streptozotocin:: Protective effects of melatonin [J].
Montilla, PL ;
Vargas, JF ;
Túnez, IF ;
Muñoz, MC ;
Valdelvira, MED ;
Cabrera, ES .
JOURNAL OF PINEAL RESEARCH, 1998, 25 (02) :94-100
[8]   Influence of melatonin and serotonin on glucose-stimulated insulin release from perifused rat pancreatic islets in vitro [J].
Peschke, E ;
Peschke, D ;
Hammer, T ;
Csernus, V .
JOURNAL OF PINEAL RESEARCH, 1997, 23 (03) :156-163
[9]   Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels [J].
Rasmussen, DD ;
Boldt, BM ;
Wilkinson, CW ;
Yellon, SM ;
Matsumoto, AM .
ENDOCRINOLOGY, 1999, 140 (02) :1009-1012