Emerging roles of insulin-like growth factor-I in the adult brain

被引：54

作者：

Fernandez, S. ^{[1
]}

Fernandez, A. M. ^{[1
]}

Lopez-Lopez, C. ^{[1
]}

Torres-Aleman, I. ^{[1
]}

机构：

[1] CSIC, Inst Cajal, Neuroendocrinol Lab, E-28002 Madrid, Spain

来源：

GROWTH HORMONE & IGF RESEARCH | 2007年 / 17卷 / 02期

关键词：

brain; astroglia; brain vessels; inflammation; cognition; aging;

D O I：

10.1016/j.ghir.2007.01.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

All tissues in the body are under the influence of insulin-like growth factor-I (IGF-I). Together with insulin, IGF-I is a key regulator of cell metabolism and growth. IGF-I also acts in the central nervous system, where it affects many different cell populations. In this brief review, we discuss the many roles of IGF-I in the adult brain, and present the idea that diseases affecting the brain will perturb IGF-I activity, although more refined studies at the molecular and cellular level are needed before we can firmly established this possibility. We also suggest that under normal physiological conditions IGF-I may play a significant role in higher brain functions underlying cognition, and may serve a homeostatic role during brain aging. Among newly emerging issues, the effects of IGF-I on non-neuronal cells within the nervous system and their impact in brain physiology and pathology are becoming very important in understanding the biology of this peptide in the brain. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：89 / 95

页数：7

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