Kasumigamide, an antialgal peptide from the cyanobacterium Microcystis aeruginosa

被引：61

作者：

Ishida, K ^{[1
]}

Murakami, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Marine Biochem Lab, Bunkyo Ku, Tokyo 1138657, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 19期

关键词：

D O I：

10.1021/jo991918f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Kasumigamide (1), a novel antialgal tetrapeptide containing an N-terminal alpha-hydroxy acid, was isolated from the freshwater cyanobacterium Microcystis aeruginosa (NIES-87). Its structure was elucidated by two-dimensional H-1-H-1 and H-1-C-13 NMR correlation experiments and confirmed by mass spectral and amino acid analyses. The absolute stereochemistry of 1 was determined by chemical studies. This peptide showed an antialgal activity against the green alga Chlamydomonas neglecta (NIES-439).

引用

页码：5898 / 5900

页数：3

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