Determination and analysis of flutamide solubility in different solvent systems at different temperatures (T=278.15-323.15 K)

被引：9

作者：

Sun, Wei ^{[1
]}

Shen, Weiliang ^{[1
]}

Xu, Hanhan ^{[1
]}

Hu, Guoxing ^{[1
]}

Deng, Zhenmei ^{[1
]}

Zhao, Guoming ^{[1
]}

Li, Fangzhao ^{[1
]}

Hu, Yonghong ^{[1
]}

Yang, Wenge ^{[1
]}

机构：

[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 South Puzhu Rd, Nanjing 211816, Peoples R China

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2021年 / 325卷

关键词：

Flutamide; Solubility; Binary solvents; KAT-LSER model; PURE SOLVENTS; THERMODYNAMIC ANALYSIS; BINARY SOLVENTS; DRUG FLUTAMIDE; HYDROCHLORIDE; MODELS; WATER; FORM;

D O I：

10.1016/j.molliq.2020.114762

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this research, the solubility properties of flutamide were studied by static equilibrium method under atmo-spheric pressure in twelve pure solvents (acetone, methanol, tetrahydrofuran, ethyl alcohol, ethyl acetate, isopropanol, n-propanol, n-butylalcohol, isobutanol, acetonitrile, methyl acetate, 1,4-dioxane) and three mixed solvents (acetone + isopropanol, ethyl acetate isopropanol, tetrahydrofuran + isopropanol) with the experiment temperature was set from 278.15 K to 323.15 K. The purpose of this article was studying the solubility properties of flutamide in diverse solvent systems, which can provide references for selecting good solvent and antisolvent in process of crystallize. Modified Apelblat and Xh model fit the solubility data which were get from pure solvents. Their RAD. were 1.73% and 2.05%, respectively, their RMSD. were 029% and 0.44%, respectively. At the same time, CNIBS/R-K and Jouyban-Acree model match the solubility data which were get from binary solvent mixtures. Their RAD(max) were 0.47% and 4.21%, respectively, their RMSDmax were 0.22% and 0.32%, respectively. (C) 2020 Elsevier B.V. All rights reserved.

引用

页数：10

共 28 条

[11] DETERMINATION OF FLUTAMIDE AND HYDROXYFLUTAMIDE IN DOG PLASMA BY A SENSITIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY METHOD UTILIZING MID-BORE CHROMATOGRAPHY [J].