Treating Atherosclerosis With Regulatory T Cells

被引：164

作者：

Foks, Amanda C. ^{[1
,2
]}

Lichtman, Andrew H. ^{[1
,2
]}

Kuiper, Johan ^{[3
]}

机构：

[1] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Leiden Univ, Gorlaeus Labs, Div Biopharmaceut, Leiden Acad Ctr Drug Res, NL-2300 RA Leiden, Netherlands

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2015年 / 35卷 / 02期

基金：

美国国家卫生研究院;

关键词：

atherosclerosis; immune system; ORAL TOLERANCE; REDUCES ATHEROSCLEROSIS; FOXP3; EXPRESSION; DENDRITIC CELLS; TGF-BETA; SUPPRESSION; ACTIVATION; INDUCTION; EFFECTOR; ATHEROGENESIS;

D O I：

10.1161/ATVBAHA.114.303568

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Regulatory T cells (Tregs) play an important role in the regulation of T-cell-mediated immune responses through suppression of T-cell proliferation and secretion of inhibitory cytokines, such as interleukin-10 and transforming growth factor-beta Impaired Treg numbers and function have been associated with numerous diseases, and an imbalance between proinflammatory/proatherogenic cells and Tregs promotes atherosclerotic disease. Restoration of this balance by inducing Tregs has great therapeutic potential to prevent cardiovascular disease. In addition to suppressing differentiation and function of effector T cells, Tregs have been shown to induce anti-inflammatory macrophages, inhibit foam cell formation and to influence cholesterol metabolism. Furthermore, Tregs suppress immune responses of endothelial cells and innate lymphoid cells. In this review, we focus on the recent knowledge on Treg subsets, their activity and function in atherosclerosis, and discuss promising strategies to use Tregs as a therapeutic tool to prevent cardiovascular disease.

引用

页码：280 / 287

页数：8

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