Determination of zopiclone in tablets by HPLC and UV-spectrophotometry

被引：12

作者：

Paw, B ^{[1
]}

Misztal, G ^{[1
]}

机构：

[1] Med Acad, Fac Pharm, Dept Med Chem, PL-20093 Lublin, Poland

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2000年 / 23卷 / 05期

关键词：

zopiclone; reversed-phase chromatography; UV-spectrophotometry; analysis in tablets;

D O I：

10.1016/S0731-7085(00)00379-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Rapid, simple and accurate chromatographic (HPLC) and spectrophotometric methods for the determination of zopiclone in tablets were elaborated. Acetonitrile was found to be a suitable extraction solvent. The samples were chromatographed on Nova-Pak C18 column and UV detection at 304 nm. The elution was achieved isocratically with a mobile phase of 0.067 M phosphate buffer pH 7.95 - acetonitrile (55:45, v/v). Diazepam was applied as an internal standard. The method was validated for precision, linearity, accuracy and limit of detection. The recovery (mean +/- SD) in HPLC was 99.85 +/- 0.04% and in the UV-spectrophotometry, 100.08 +/- 0.09%. (C) 2000 Published by Elsevier Science B.V.

引用

页码：819 / 823

页数：5

共 4 条

[1] QUANTITATIVE-ANALYSIS OF ZOPICLONE IN TABLETS USING ION-SELECTIVE ELECTRODE AND POLAROGRAPHIC METHODS [J].

BOUKLOUZE, AA ;

VIRE, JC ;

QUARIN, GC ;

KAUFFNANN, JM .

ELECTROANALYSIS, 1994, 6 (11-12) :1045-1050

[2] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC STABILITY-INDICATING DETERMINATION OF ZOPICLONE IN TABLETS [J].

BOUNINE, JP ;

TARDIF, B ;

BELTRAN, P ;

MAZZO, DJ .

JOURNAL OF CHROMATOGRAPHY A, 1994, 677 (01) :87-93

[3] GAS-CHROMATOGRAPHIC DETERMINATION OF ZOPICLONE IN PLASMA AFTER SOLID-PHASE EXTRACTION [J].

GAILLARD, Y ;

GAYMONTCHAMP, JP ;

OLLAGNIER, M .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1993, 619 (02) :310-314

[4]

SQUELLA JA, 1994, J AOAC INT, V77, P768

← 1 →