Mitotic histone H3 phosphorylation by the NIMA kinase in Aspergillus nidulans

被引：121

作者：

De Souza, CPC ^{[1
]}

Osmani, AH ^{[1
]}

Wu, LP ^{[1
]}

Spotts, JL ^{[1
]}

Osmani, SA ^{[1
]}

机构：

[1] Geisinger Med Clin, Weis Ctr Res, Henry Hood Res Program, Danville, PA 17822 USA

来源：

CELL | 2000年 / 102卷 / 03期

关键词：

D O I：

10.1016/S0092-8674(00)00035-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorylation of histone H3 serine 10 correlates with chromosome condensation and is required for normal chromosome segregation in Tetrahymena. This phosphorylation is dependent upon activation of the NIMA kinase in Aspergillus nidulans. NIMA expression also induces Ser-10 phosphorylation inappropriately in S phase-arrested cells and in the absence of NIMXcdc2 activity. At mitosis, NIMA becomes enriched on chromatin and subsequently localizes to the mitotic spindle and spindle pole bodies. The chromatin-like localization of NIMA early in mitosis is tightly correlated with histone H3 phosphorylation. Finally, NIMA can phosphorylate histone H3 Ser-10 in vitro, suggesting that NIMA is a mitotic histone H3 kinase, perhaps helping to explain how NIMA promotes chromatin condensation in A. nidulans and when expressed in other eukaryotes.

引用

页码：293 / 302

页数：10

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